MECHANISM OF THE HOST RANGE TRANSMISSION OF INFLUENZA VIRUS AND ITS CONTROL

1.我们发现1999年从香港鹌鹑和鸡中分离的部分流感病毒的血凝素（HA）中负责识别宿主细胞受体唾液糖链的第226位氨基酸由鸟型变为人型。这些表明，直接传播，没有中间宿主，猪，2.发现了一种新的神经节苷脂，它是一种新的神经节苷脂，它的结构与人的神经节苷脂的结构相似，是一种新的神经节苷脂，它的结构与人的神经节苷脂的结构相似，是一种新的神经节苷脂，它的结构与人的神经节苷脂的结构相似神经节苷脂与人、禽、猪、马等动物的流感病毒结合，提示神经节苷脂可能是人和其他动物流感病毒的共同受体。3.香港流感（A/1968，H3 N2）中人病毒的神经氨酸酶亚型具有禽流感的特性（在酸性pH下稳定）。发现1971年以后分离的H_3N_2亚型人流感病毒的N_2亚型不是香港流感N_2.4亚型的慢病毒。本研究发现并分离了几种新的流感病毒HA的抑制剂，如携带唾液酸乳糖胺的聚合物、与HA受体结合袋结合的唾液酸乳糖连接的环肽、从细菌中分离的甘油糖脂等。

1.We found that the amino acid No.226 in the hemagglutinin (HA) of a part of the influenza viruses isolated from quail and chicken in Hong Kong (1999), which is responsible for the recognition of the host cell receptor sialosugar chains, has been changed from bird type to human type. These indicate that the direct transmission, without the intermediate host, pig, of the quail and chicken influenza viruses transmitted from wild duck to human will be possible if the receptor binding specificity of the bird virus is changed to human type the substitution of the amino acid 226 in the HA from bird type to human type by the evolutional selection of the receptor sialo sugar chains.2.We found a new ganglioside which binds every influenza viruses isolated from the hosy, sucu as human, bird, pig and horset, indicating that this ganglioside may be a common receptor for the influenza viruses of human and other animals.3.The neuraminidase subtype of the human virus at the Hong Kong Flu (A/1968, H3N2) has a properties of the bird flu (stable in acidic pH). It was found that the N2 subtypes of the H3N2 human influenza viruses isolated after 1971 is not a leneage of the Hong Kong Flu N2.4.Several new inhibitors for the influenza virus HA such as polymer carrying sialyllactosamine, cyclic peptide conncted with sialyllactose which binds receptor binding pocket in the HA, glyceroglycolipids isoated from bacteria etc. were found and isolated in this study.