The study to elucidate the mechanisms of influences of catastrophic stress and coping style on endocrine systems, memory, and emotion.

本研究的目的是通过测量心理社会因素或脑功能来研究心理困扰（癌症相关回忆或重度抑郁）与区域脑容量（海马体或杏仁核）之间的关系。本研究经日本国立癌症中心机构审查委员会和伦理委员会批准，并在获得受试者知情同意后进行。研究对象为1998年2月至1999年4月在东部国家癌症中心医院接受乳腺癌手术后存活3年以上的女性患者（<55岁）。我们通过DSM-4的半结构化临床诊断访谈来评估受试者的癌症相关回忆和重度抑郁，以调查这些症状与社会心理因素以及这些症状与大脑形态之间的关系。心理因素采用情绪状态量表、心理适应量表和事件影响量表进行评估。社会因素通过访谈和临床图表复习得到。脑图像在1.5 t MRI单元（GE Signa扫描仪）上生成，三维破坏梯度回忆采集1.5 mm连续切片。使用analysis - pc软件手工追踪海马、杏仁核、全脑体积和颅内体积。研究结果表明，与癌症相关的回忆与焦虑的事前工作之间存在关联。研究还表明，与癌症相关的回忆与左侧海马体和杏仁核的小容量有关，但严重抑郁症与任何区域容量无关。然而，由于横断面设计，我们无法阐明这些关联的因果关系。此外，癌症本身的影响也不清楚，因为没有健康对照的数据。因此，需要进一步的纵向设计和健康对照研究来详细调查这些关联。少

The aim of this study was to investigate the association between psychological distress (cancer-related recollection or major depression) and regional brain volume (hippocampus or amygdale) by the measurement of psycho-social factors or brain functions. The present research was approved by Institutional Review Board and the Ethics Committee of the National Cancer Center, Japan, and performed after getting informed consents of the subjects. The subjects were female patients (<55 years old) who had been survived 3 or more years after their breast cancer surgery between February 1998 and April 1999 at National Cancer Center Hospital, East. We assessed cancer-related recollection and major depression in the subjects by semi-structured clinical diagnostic interview for DSM-4 to investigate the association between these symptoms and psychosocial factors and between these symptoms and brain morphology. Psychological factors were assessed by the Profile of Mood States, Mental Adjustment to Can … More cer scale, and the Impact of Event Scale. Social factors were obtained by interviewing and clinical chart review. Brain images were generated on a 1.5-T MRI unit (GE Signa scanner) with three-dimensional spoiled gradient-recalled acquisition of 1.5-mm contiguous sections. Volumes of hippocampus, amygdala, and whole brain, and intracranial volume were traced manually using ANALYZE-PC software. The results suggested the association between cancer-related recollection and anxious pre-occupation. And it also suggested the association between cancer-related recollection and small volume of left hippocampus and amygdala, but no association between major depression and any regional volumes. However, we could not elucidate the causality of these associations due to cross-sectional design. Besides, the influences of cancer itself were not clear because no data in healthy controls were available. Therefore, further research with longitudinal design with healthy controls is needed to investigate these associations in detail. Less