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The study to elucidate the mechanisms of influences of catastrophic stress and coping style on endocrine systems, memory, and emotion.

该研究旨在阐明灾难性压力和应对方式对内分泌系统、记忆和情绪的影响机制。

基本信息

批准号：
13470100
负责人：
UCHITOMI Yosuke
金额：
$ 6.66万
依托单位：
National Cancer Center Research Institute East
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

The aim of this study was to investigate the association between psychological distress (cancer-related recollection or major depression) and regional brain volume (hippocampus or amygdale) by the measurement of psycho-social factors or brain functions. The present research was approved by Institutional Review Board and the Ethics Committee of the National Cancer Center, Japan, and performed after getting informed consents of the subjects. The subjects were female patients (<55 years old) who had been survived 3 or more years after their breast cancer surgery between February 1998 and April 1999 at National Cancer Center Hospital, East. We assessed cancer-related recollection and major depression in the subjects by semi-structured clinical diagnostic interview for DSM-4 to investigate the association between these symptoms and psychosocial factors and between these symptoms and brain morphology. Psychological factors were assessed by the Profile of Mood States, Mental Adjustment to Can … More cer scale, and the Impact of Event Scale. Social factors were obtained by interviewing and clinical chart review. Brain images were generated on a 1.5-T MRI unit (GE Signa scanner) with three-dimensional spoiled gradient-recalled acquisition of 1.5-mm contiguous sections. Volumes of hippocampus, amygdala, and whole brain, and intracranial volume were traced manually using ANALYZE-PC software. The results suggested the association between cancer-related recollection and anxious pre-occupation. And it also suggested the association between cancer-related recollection and small volume of left hippocampus and amygdala, but no association between major depression and any regional volumes. However, we could not elucidate the causality of these associations due to cross-sectional design. Besides, the influences of cancer itself were not clear because no data in healthy controls were available. Therefore, further research with longitudinal design with healthy controls is needed to investigate these associations in detail. Less

本研究的目的是通过测量心理社会因素或脑功能来探讨心理困扰（癌症相关回忆或重性抑郁）与局部脑容量（海马或杏仁核）之间的关系。本研究得到了日本国立癌症中心机构审查委员会和伦理委员会的批准，并在获得受试者知情同意后进行。受试者为1998年2月至1999年4月在美国东部国家癌症中心医院接受乳腺癌手术后存活3年或3年以上的女性患者（<55岁）。我们通过DSM-4的半结构化临床诊断访谈评估了受试者的癌症相关回忆和重度抑郁，以调查这些症状与心理社会因素之间的关联以及这些症状与脑形态之间的关联。心理因素采用情绪状态量表、心理适应量表、心理健康量表进行评定。 ...更多信息 cer量表和事件影响量表。社会因素通过访谈和病历回顾获得。在1.5-T MRI装置（GE Signa扫描仪）上生成脑图像，并对1.5 mm连续切片进行三维破坏梯度回忆采集。使用ANALYZE-PC软件手动追踪海马、杏仁核和全脑的体积以及颅内体积。结果表明癌症相关的回忆和焦虑的前职业之间的联系。癌症相关回忆与左侧海马和杏仁核体积小有关，而抑郁症与任何区域体积无关。然而，由于采用横断面设计，我们无法阐明这些关联的因果关系。此外，癌症本身的影响尚不清楚，因为没有健康对照组的数据。因此，需要进一步的研究与健康对照组的纵向设计，详细调查这些协会。少