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Development of surface modification technology of titanium alloys for artificial bones using phosphate glasses

磷酸盐玻璃人工骨钛合金表面改性技术开发

基本信息

批准号：
13555173
负责人：
KASUGA Toshihiro
金额：
$ 6.21万
依托单位：
Nagoya Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13555173/
关键词：
Phosphate glass Bonelike apatite Glass Glass-ceramic Bioactivity Simulated body fluid Titanium alloy High strength

项目摘要

A bioactive calcium phosphate invert glass-ceramic containing β-Ca_3(PO_4)_2 crystals could be joined strongly with a Ti-29Nb-13Ta-4.6Zr alloy consisting of a β-titanium phase by heating the metal, on which the mother glass powders with a composition 60CaO-30P_2O_5-7Na_2O-3TiO_2 in mol% were placed, at 800℃ for 1 h in air ; the tensile joining strength was estimated to be 〜26MPa on average. A compositionally gradient layer was developed on the metallic substrate during the heating. The joining between the glass-ceramic and the metal is suggested to be controlled by viscous, flow of the glassy phase in the glass-ceramic and by reaction of the glassy phase with the oxide phase formed around the surface layer of the metal.Bonelike apatite formation was observed on the glass-ceramic after 20 days of soaking in simulated body fluid (SBF). We found the apatite-forming ability of the glass-ceramic can be easily improved by autoclaving treatment in water. When the autoclaved sample was soaked in SBF, bonelike apatite began to form after 3 days. On the other hand, no apatite formed on the glass-ceramic, which was not autoclaved, even by soaking in SBF for 10 days. During the autoclaving, titanium ions in the amorphous phases around the surface form anatase phase and the hydrated titania groups, which may play an important role in the apatite formation.. A rod sample of the treated titanium alloy was implanted into a femur of rabbit. After 4-week implantation, newly formed bones were seen around the sample and they contacted directly without fibrous tissue.

在含有β-Ca3(PO4)2晶体的生物活性磷酸钙倒置微晶玻璃上，加入摩尔分数为60CaO-30P_2O_5-7Na_2O-3TiO_2的母体玻璃粉末，在800℃、空气中保温1h，可实现与含钛相的Ti-29Nb-13Ta-4.6Zr合金的强力连接，平均抗拉强度约为26 Mpa。在加热过程中，在金属衬底上形成了成分梯度层。认为微晶玻璃与金属的结合是由玻璃相在微晶玻璃中的粘性流动以及玻璃相与金属表层形成的氧化物相的反应控制的。研究发现，在水中蒸压处理可以很容易地提高微晶玻璃的磷灰石形成能力。在SBF中浸泡3天后，样品开始形成骨状磷灰石。而未经高压灭菌的微晶玻璃，即使在SBF中浸泡10天，也没有形成磷灰石。在高压灭菌过程中，表面周围无定形相中的钛离子形成锐钛矿相和水合二氧化钛基团，这可能在磷灰石的形成中起着重要作用。将处理后的钛合金棒状样品植入兔股骨内。植入4周后，在标本周围可见新生骨，它们之间直接接触，没有纤维组织。