Preparation of Bioresorbable Nanoporous Fibermats for Bone Regeneration in a Dental Field

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Novel bioresorbable materials with silicate and calcium ions-releasing ability for enhancing bone formation were prepared using composites consisting of siloxane, poly (lactic acid) and calcium carbonate. They could be shaped into nonwoven fibermats of 100～200μm-thickness, consisting of nanoporous fibers of～10μm in diameter. Cell culture tests showed that this dimensional design induced the 3D proliferation of bone-forming cells. The materials were confirmed by animal tests using rabbits to show excellent bone formation. They are expected to be applicable to membranes for guided bone regeneration in a dental field.