Preparation and Biomechanics of High-performance Artificial Bones Containing

高性能人工骨的制备及其生物力学

• 批准号: 09680851
• 负责人: KASUGA Toshihiro
• 金额: $ 1.66万
• 依托单位: Nagoya Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09680851/
• 关键词: Glass-Ceramic; Calcium phosphate; Fiber; Polylactic acid; Artificial bone; Young's modulus; Composite; Biomaterial; 結晶化ガラス

Novel biomaterials for application to artificial bone with modulus of elasticity close to that of natural bone were prepared using bioresorbable poly-L-lactic acid (PLA) and high strength β-Ca(POィイD23ィエD2)ィイD22ィエD2 fibers (CPF) treated with dilune NaOH solution. PLA dissolved by using methylene chloride was mixed with the fibers. After drying the mixture, it was hot-pressed uniaxially under a pressure of 40 MPa at 180℃, resulting in fabrication of a PLA-composite containing CPF. Almost no degradation in the bending strength was observed even when a large amount of the fibers (【approximately equal】50 wt%) was introduced, and the modulus of elasticity was increased effectively with increasing the fiber content. The PLA-composite with modulus of elasticity of >5 GPa similar to that of natural bone was found to be prepared when the fiber content was over 35 wt%. The bending test of the composites showed that very high energy is consumed for their fracture and that the fracture proceeds ste … More p by step, even beyond the maximum stress.After the PLA sample was soaked in simulated body fluid (SBF) for 90 days, the maximum stress was decreased extremely and the specimen showed typical brittle fracture similar to that of conventional ceramics. Hardening originated from hydrolysis of PLA is supported to suppress degradation of the materials in modulus of elasticity, although the maximum stresses are decreased. The PLA-composite containing 35% CPF showed the characteristic fracture pattern even after the soaking for 90 days in control to that PLA. Hydrolysis of PLA induces serious degradation in the composite would be also converted into a brittic material by the soaking in SBF as well as the PLA sample without CPF. However, since CPF in the composite can share an applied load successfully, the material shows non-catastrophic fracture even after the soaking. Hybridization of CPF into PLA as a matrix phase has great advantages that modulus of elasticity is improved to the value close to that of natural bone and that degradation of the material in toughness in a wet environment is relatively restricted. The mechanical properties of the PLA composites are expected to meet the biomechanical requirements of some applications such as bone plates or temporary internal fixation of bones broken damaged. Less

以聚L-乳酸（PLA）和高强度β-Ca（PO）_2D_2D_2D_2纤维（CPF）为原料，经氢氧化钠溶液处理，制备了弹性模量接近天然骨的新型人工骨材料。将用二氯甲烷溶解的PLA与纤维混合。将混合物干燥后，在180℃下在40 MPa的压力下进行单轴热压，从而制备含有CPF的PLA复合材料。即使引入大量纤维（[约等于]50重量%），也几乎没有观察到弯曲强度的降低，并且随着纤维含量的增加，弹性模量有效地增加。当纤维含量超过35wt%时，可制备弹性模量> 5GPa的PLA复合材料，其弹性模量与天然骨的弹性模量相似。复合材料的弯曲试验表明，复合材料的断裂消耗很大的能量，断裂过程是在应力作用下进行的。 ...更多信息 在模拟体液（SBF）中浸泡90 d后，PLA试样的最大应力急剧下降，试样呈现出与普通陶瓷相似的典型脆性断裂。支持源自PLA水解的硬化以抑制材料的弹性模量的退化，尽管最大应力降低。含35%CPF的PLA-复合材料即使在浸泡90天后也显示出与PLA对照的特征性断裂模式。PLA的水解会导致复合材料严重降解，浸泡在SBF中也会转化为脆性材料，不含CPF的PLA样品也是如此。然而，由于复合材料中的CPF可以成功地分担施加的载荷，即使在浸泡后，材料也显示出非灾难性的断裂。将CPF杂化到作为基质相的PLA中具有很大的优点，即弹性模量提高到接近天然骨的弹性模量的值，并且材料在潮湿环境中韧性的降解相对受到限制。聚乳酸复合材料的力学性能有望满足某些应用的生物力学要求，如接骨板或骨断裂损伤的临时内固定。少

项目成果

T.Kasuga,et al.: "Preparation of polylactic acid composites containing β-Ca(PO_3)_2 fibers"J.Mater.Res.. 14. 418-424 (1999)

T. Kasuga 等人：“含有 β-Ca(PO_3)_2 纤维的聚乳酸复合材料的制备”J. Mater. 14. 418-424 (1999)

T.Kasuga,et al.: "New Calcium Phosphate Glass-Ceramics Prepared by Crystallization and Sintering of Glass Pouders" Proceedings of 18th International Congress on Glass. E4. 31-36 (1998)

T.Kasuga等人：“通过玻璃粉结晶和烧结制备新型磷酸钙玻璃陶瓷”第18届国际玻璃大会论文集。

T. Kasuga, 他: "Surface modification of calcium metaphosphate fibers"J. Mater. Sci. : Mater. Med.. 11(印刷中). (2000)

T. Kasuga 等人：“偏磷酸钙纤维的表面改性”J. Mater. ：Mater. 11（出版中）。

Toshihiko Kasuga, Yoshio Ota, Masayuki Nogami, and Yoshihiro Abe: "Surface Modification of Calcium Metaphosphate Fibers"J. Mater. Sci. : Mater Med.. 11 (in press). (2000)

Toshihiko Kasuga、Yoshio Ota、Masayuki Nogami 和 Yoshihiro Abe：“偏磷酸钙纤维的表面改性”J。

Toshihiko Kasuga, Yoshio Ota, Shin-ya Ozaki, Tomokatsu Hayakawa, Masayuki Nogami, and Yoshihiro Abe: "Mechanical Properties of Polylatic Acid Composites Containing β-Ca(POィイD23ィエD2)ィイD22ィエD2 Fibers"Phosphorus Res. Bull.. 10. 640-645 (1999)

Toshihiko Kasuga、Yoshio Ota、Shin-ya Ozaki、Tomokatsu Hayakawa、Masayuki Nogami 和 Yoshihiro Abe：“含有 β-Ca(POiiD23ieD2)iiD22ieD2 纤维的聚乳酸复合材料的机械性能”Phosphorus Res.. 10. 640-645 ( 1999）