A new liquid embolic material for transcatheter hepatic arterial embolization

一种用于经导管肝动脉栓塞的新型液体栓塞材料

• 批准号: 13557076
• 负责人: SAWADA Satoshi
• 金额: $ 6.14万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557076/
• 关键词: HCC; Embolization; TAE; Onyx; EVOH; Rabbit; Liver tumor model; Embolic material

Purpose:To evaluate the feasibility of a new liquid embolic material, 'Onyx', for treating liver tumor.Material and Methods:'Onyx' is a mixture of 6%(w/v) ethylene-vinyl alcohol polymer dissolved in anhydrous dimethyl sulfoxide (DMSO) with 28%(w/v) tantalum powder. In addition to 6% Onyx, we also tried 4%, 2% and 1% solutions, prepared by adjusting the amount of DMSO. We used 15 white rabbits with liver tumors created by percutaneous injection of VX2 tumor cells. In 4 groups with 3 rabbits in each, the liver arteries were embolized with 6%, 4%, 2% and 1% Onyx, respectively, and in 3 rabbits DMSO alone was injected. The injections were performed just proximal to the bifurcation of the proper hepatic artery, followed by celiac arteriography. Post mortem, the livers were examined by soft tissue radiography, and liver-tissue sections microscopically.Results:The maximum number of arterial branching points passed by embolic material in either right or left hepatic arteries was 11, 15 and 16, for 6%, 4% and 2% Onyx, respectively, but was non-measurable for 1% Onyx. Minimum diameters of arteries reached by 6%, 4%, 2% and 1% Onyx in tumorous areas were 40μm, 35μm, 20μm and 10μm, respectively, and in non-tumorous areas 35μm, 5μm, 5μm and 5μm, respectively.Conclusion:This study suggests that Onyx may be feasible for treatment of hepatic tumors.

目的：评估新型液体栓塞材料“Onyx”治疗肝肿瘤的可行性。材料和方法：“Onyx”是溶解在无水二甲亚砜（DMSO）中的 6%（w/v）乙烯-乙烯醇聚合物与 28%（w/v）钽粉的混合物。除了6% Onyx之外，我们还尝试了4%、2%和1%的溶液，通过调整DMSO的量来制备。我们使用了 15 只患有肝脏肿瘤的白兔，这些肿瘤是通过经皮注射 VX2 肿瘤细胞产生的。 4组，每组3只兔子，分别用6%、4%、2%和1% Onyx栓塞肝动脉，其中3只兔子单独注射DMSO。在靠近肝固有动脉分叉处进行注射，然后进行腹腔动脉造影。死后，通过软组织射线照相和显微镜下肝组织切片检查肝脏。结果：对于 6%、4% 和 2% Onyx，右肝动脉或左肝动脉中栓塞物质通过的动脉分支点的最大数量分别为 11、15 和 16，但对于 1% Onyx 则无法测量。 6%、4%、2%和1% Onyx在肿瘤区域达到的动脉最小直径分别为40μm、35μm、20μm和10μm，在非肿瘤区域分别为35μm、5μm、5μm和5μm。结论：本研究表明Onyx可能用于治疗肝脏肿瘤。

项目成果

Atsushi Komemushi: "An animal experimental study using Onyx: A new liquid embolic material for liver tumor"Acta Radiol.. 43 (2). 186-191 (2002)

Atsushi Komemushi：“使用 Onyx 的动物实验研究：一种用于肝肿瘤的新型液体栓塞材料”Acta Radiol.. 43（2）。

Atsushi Komemushi: "An animal experimental study using Onyx : A new liquid embolic material"Acta Radiologica. 43. 186-191 (2002)

Atsushi Komemushi：“使用 Onyx 进行的动物实验研究：一种新型液体栓塞材料”Acta Radiologica。

Kiomemushi Atsushi: "An animal experimental study using Onyx : A new liquid embolic material for liver tumor"Acta Radiologica. (In Press). (2002)

Kiomemushi Atsushi：“使用 Onyx 进行的动物实验研究：一种治疗肝肿瘤的新型液体栓塞材料”Acta Radiologica。

米虫 敦, 谷川 昇: "IVRの基本 器具・材料と基本的手技 塞栓物質"pp.19-23,IVRの技法,南江堂,東京,中村仁信、澤田敏、村上卓道、谷川昇編. 5 (2002)

Atsushi Yonemushi、Noboru Tanikawa：“IVR 基础：仪器/材料和基本技术：栓塞物质”第 19-23 页，IVR 技术，Nankodo，东京，由 Hitoshi Nakamura、Satoshi Sawada、Takudo Murakami 和 Noboru Tanikawa 编辑 5。 (2002)

澤田 敏: "IVRの技法 第3章 6.オニクス"南江堂(印刷中). (2002)

Satoshi Sawada：“IVR 技术第 3 章 6.Onyx”Nankodo（印刷中）。