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Usefulness of New Liquid Embolic Material for Liver tumor

新型液体栓塞材料在肝脏肿瘤治疗中的应用

基本信息

批准号：
12670911
负责人：
SAWADA Satoshi
金额：
$ 2.24万
依托单位：
Kansai Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670911/
关键词：
HCC Embolization TAE Onyx EVOH Rabbit Liver tumor model Embolic material EVOH

项目摘要

Purpose : To evaluate the feasibility of a new liquid embolic material, 'Onyx', for treating liver tumor.Material and Methods : 'Onyx' is a mixture of 6%(w/v) ethylene-vinyl alcohol polymer dissolved in anhydrous dimenthyl sulfoxide (DMSO) with 28% (w/v) tantalum powder. In addition to 6% Onyx, we also tried 4%, 2% and 1% solutions, prepared by adjusting the amount of DMSO. We used 15 white rabbits with liver tumors created by percutaneous injection of VX2 tumor cells. In 4 groups with 3 rabbits in each, the liver arteries were embolized with 6%, 4%, 2% and 1% Onyx, respectively, and in 3 rabbits DMSO alone was injected. The injections were performed just proximal to the bifurcation of the proper hepatic artery, followed by celiac arteriography. Post mortem, the livers were examined by soft tissue radiography, and liver-tissue sections microscopically.Results : The maximum number of arterial branching points passed by embolic material in either right or left hepatic arteries was 11, 15 and 16, for 6%, 4% and 2% Onyx, respectively, but was non-measurable for 1% Onyx. Minimum diameters of arteries reached by 6%, 4%, 2% and 1% Onyx in tumorous areas were 40μm, 35μm, 20μm and 10μm, respectively, and in non-tumorous areas 35μm, 5μm, 5μm and 5μm, respectively.Conclusion : This study suggests that Onyx may be feasible for treatment of hepatic tumors.

目的：评价一种新型液体栓塞材料“玛瑙”治疗肝脏肿瘤的可行性。材料和方法：“Onyx”是6%（w/v）乙烯-乙烯醇聚合物溶解在无水二甲基亚砜（DMSO）中，与28% （w/v）钽粉的混合物。除了6%的玛瑙外，我们还尝试了4%，2%和1%的溶液，通过调整DMSO的量来制备。我们使用15只经皮注射VX2肿瘤细胞造成肝脏肿瘤的大白兔。4组，每组3只兔，分别用6%、4%、2%和1%的玛玛石栓塞肝动脉，3只兔单独注射DMSO。注射在肝固有动脉分叉的近端进行，随后进行腹腔动脉造影。死后，用软组织x线摄影检查肝脏，并用显微镜检查肝脏组织切片。结果：6%、4%、2%玛瑙的右、左肝动脉栓塞物通过的最大动脉分支点分别为11个、15个、16个，1%玛瑙无法测量。肿瘤区6%、4%、2%、1%玛石的最小动脉直径分别为40μm、35μm、20μm、10μm，非肿瘤区35μm、5μm、5μm、5μm。结论：本研究提示玛瑙治疗肝脏肿瘤是可行的。