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DEVELOPMENT OF PERITONEAL DIALYSIS SYSTEM WITH A WEARABLE ARTIFICIAL KIDNEY UNDER NO DIOALYSATE REPLACEMENT

无需更换透析液的可穿戴式人工肾腹膜透析系统的开发

基本信息

批准号：
13558118
负责人：
MINESHIMA Michio
金额：
$ 5.82万
依托单位：
TOKYO WOMEN'S MEDICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

In this study, we introduced a modified CRPD/BPD system with a newly developed wearable artificial kidney and utilizing albumin solution as an osmotic agent. Water and solute removal characteristics in this system were examined during an canine in vitro experiemts.1)Wearable artificial kidney : As a result of preliminary study beased on parformance of a test daialyzer with a specific cellulose triacetate membrane, specifications of the optimum dialyzer colud be determined during an analytical study. This dialyzer will be used for the regeneration of the spent peritoneal dialysate in the CRPD/BPD system. A wearable dialyzer was developed by a co-investigator in this research, Hiroyuki Hattori, belonging to Nipro Company Limited on an account of an economical viewpoint.2)Canine in vitro experiments : Peritoneal dialysis experiments using bilaterally nephrectomized dogs were carried out to examine the water and solute removal characteristics in this system. Before the start of the experiment, an solution involving several marker solutes was infused ti the dog. Time corce of solute concentration of the marker was obtained and sevreal parameters such as nass transfer-area coefficient was determined by a simulation method.3)Albumin additive dialysate : In order to exmine a validity of the dialysate containing albumin as an osmotic agent, canine in vitro experiemnts were carried out. A combination of 10 % albumin with 1.0 % glucose was most effective for water removal in a clinical situation.

在这项研究中，我们介绍了一种改进的CRPD/BPD系统与新开发的可穿戴人工肾和利用白蛋白溶液作为渗透剂。1）穿戴式人工肾：在对一种具有特殊三醋酸纤维素膜的透析器进行初步研究的基础上，通过分析研究确定了最佳透析器的规格。该透析器将用于再生CRPD/BPD系统中用过的腹膜透析液。本研究中的合作研究者Hiroyuki Hattori（属于Nipro Company Limited）出于经济的观点开发了一种可穿戴透析器。2）犬体外实验：使用双侧肾切除犬进行腹膜透析实验，以检查该系统中的水和溶质去除特性。在实验开始前，向犬输注含有几种标记物溶质的溶液。通过模拟实验，获得了该标记物的溶质浓度时间曲线，并确定了纳斯传递面积系数等参数。3）白蛋白透析液：为了验证含白蛋白透析液作为渗透剂的有效性，进行了犬体外实验。在临床情况下，10%白蛋白与1.0%葡萄糖的组合对于除水最有效。