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Development of home hemodialysis system with navigator

带导航仪的家庭血液透析系统的开发

基本信息

批准号：
19500397
负责人：
MINESHIMA Michio
金额：
$ 2.75万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2010
项目状态：
已结题

项目摘要

In recently, more than 300,000 patients with chronic renal failure receive hemodialysis (HD) therapy in Japan. However, life expectancy of those dialysis patients estimates roughly half as that in healthy subjects. Further improvements of the dialysis system are required for promoting health and longevity of the patient. In this situation, the aim of this study is development of home hemodialysis system with navigator in safety. Concretely, continuous monitoring systems for dialyzer performances and solute removal characteristics during the treatment have been developed to navigate the optimal dialysis conditions for each patient.We carried out in vitro experiments with whole bovine blood or bovine plasma to evaluate the dialyzer performance such as solute clearances and hydraulic permeability. Furthermore, internal filtration flow rate of a dialyzer was measured using laser Doppler sonography during bovine plasma experiments. And, continuous monitoring of solute concentration in the spent dialysate was done for the development of the dialysis system with navigator.From these results, we obtained time courses of data for hydraulic permeability, internal filtration flow rate and solute removal efficiency during the experiments. Time dependency of those performances seems to be induced by membrane fouling, namely, protein plugging to the membrane.We have developed an analytical model for estimating the dialyzer performances based on mass transport and momentum change in the dialyzer. And some parameters such as hydraulic permeability were determined using the fitting method to the experimental data.During our study, we have reached some conclusionsDevelopment of fundamental techniques and collecting some knowledge are done for the dialysis system with navigator at home. Development of a dialysis machine with navigation system is required for optimum dialysis for each patient in the near future.

最近，在日本有超过30万名慢性肾衰竭患者接受血液透析（HD）治疗。然而，这些透析患者的预期寿命估计大约是健康受试者的一半。需要进一步改进透析系统以促进患者的健康和长寿。在这种情况下，本研究的目的是开发一种安全的家庭血液透析系统与导航。具体地说，连续监测系统的透析器性能和溶质清除特性在治疗过程中已经开发出导航的最佳透析条件为每个patient.We进行了体外实验与全牛血或牛血浆，以评估透析器的性能，如溶质清除率和水力渗透性。此外，在牛血浆实验期间，使用激光多普勒超声测量透析器的内部过滤流速。同时，在透析系统的开发过程中，对透析液中的溶质浓度进行了连续监测，得到了实验过程中渗透率、内过滤流速和溶质去除效率的时间过程数据。这些性能的时间依赖性似乎是由膜污染，即蛋白质堵塞的membrane.We开发了一个分析模型，用于估计透析器性能的基础上，在透析器中的质量传递和动量变化。通过对实验数据的拟合，确定了透析系统的渗透率等参数，并得出了一些结论。在不久的将来，需要开发具有导航系统的透析机，以便为每位患者提供最佳透析。