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The mechanisms of information processing for reward and aversion in the insular cortex of monkeys and rats.

猴子和大鼠岛叶皮层奖励和厌恶的信息处理机制。

基本信息

批准号：
14580768
负责人：
TAMURA Ryoi
金额：
$ 2.3万
依托单位：
Toyama Medical and Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14580768/
关键词：
monkeys rats insular cortex behavior single unit recording taste responses emotion learning 報酬遅延反応遅延報酬課題

项目摘要

The aim of this study was to elucidate, at neuronal level, the role of the insular cortex for the expression of emotional behaviors in monkeys and rats. In the first fiscal year (2002), single neuron activity was recorded from the monkey insular cortex during performance of a delayed-response delayed-reward go/nogo task ; and responsiveness to the task was analyzed. As a result, we found that there are neurons related to attention, reward anticipation or behavioral decision making in the insular cortex ; we also found that there are functional topography in the insula. In the second fiscal year (2003), we recorded single neuron activity in the gustatory insular cortex of alert rats, and analyzed responses to rewarding or aversive taste stimuli. As a result, we found that some insular neurons responded differentially to the 4 standard taste stimuli (sweet, salty, sour and bitter). In addition to these taste cells, we found some neurons specifically responding to water or rinse. The cells best responding to salty or bitter tended not to respond to other taste stimuli but their own best stimulus, while for the sweet-best cells, the responses to sweet were almost similar to those to sour ; for the sour-best cells, the responses to sweet, sour and bitter were considerably similar. When considering the fact that sweet has innately hedonic while sour or bitter has an aversive property, the present results suggested that the insular neurons play an important role in the coding of taste quality. In the final fiscal year (2004), neural activity was recorded from the rat insular cortex during performance of a stimulus-reward/aversion association task, and responsiveness to the task was analyzed. As a result, we found that some insular neurons specifically code tones with biological significance.

本研究的目的是在神经元水平上阐明岛叶皮层在猴子和大鼠情绪行为表达中的作用。在第一个财政年度（2002年），在执行延迟反应-延迟奖励-去/不去任务时，记录了猴子岛叶皮层的单个神经元活动；对任务的反应性进行了分析。结果，我们发现岛叶皮层中有与注意力、奖励预期或行为决策相关的神经元；我们还发现脑岛有功能性地形。在第二个财政年度（2003年），我们记录了警觉大鼠味觉岛皮层的单个神经元活动，并分析了对奖励或厌恶的味觉刺激的反应。结果，我们发现一些岛状神经元对4种标准味觉刺激（甜、咸、酸和苦）的反应不同。除了这些味觉细胞，我们还发现一些神经元对水或漂洗物有特殊反应。对咸味和苦味反应最好的细胞倾向于对自己最好的刺激而不是对其他味道刺激作出反应，而对甜味最好的细胞对甜味的反应与对酸味的反应几乎相似；对于最耐酸的细胞来说，对甜、酸和苦的反应相当相似。考虑到甜味具有天生的享乐性，而酸或苦具有厌恶性，本研究结果表明，岛状神经元在味觉质量编码中起重要作用。在最后一个财政年度（2004年），记录了大鼠在执行刺激-奖励/厌恶关联任务时的神经活动，并分析了对任务的反应性。结果，我们发现一些岛状神经元专门编码具有生物学意义的音调。

项目成果

期刊论文数量（75）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place.

DOI：
10.1073/pnas.0409726102
发表时间：
2005-02
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
A. Tran;R. Tamura;T. Uwano;Tsuneyuki Kobayashi;M. Katsuki;T. Ono
通讯作者：
A. Tran;R. Tamura;T. Uwano;Tsuneyuki Kobayashi;M. Katsuki;T. Ono

Tamura, R., Norgren, R.: "Intracranial renin alters gustatory neural responses in the nucleus of the solitary tract of rats"Am. J. Physiol.. (in press).

Tamura, R., Norgren, R.：“颅内肾素改变大鼠孤束核中的味觉神经反应”Am。