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Dependency of Place Representation in Hippocampal Neural Activity on Translocation Mode.

海马神经活动的位置表征对易位模式的依赖性。

基本信息

批准号：
11680805
负责人：
TAMURA Ryoi
金额：
$ 2.37万
依托单位：
Toyama Medical and Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680805/
关键词：
hippocampalformation monkeys rats learning memory spatial recognition single unit activity electroencephalograph 行動

项目摘要

The purposes of this study are to investigate 1) the effects of translocation modes (active and passive) and cognitive requirement of spatial tasks on the activity of hippocampal place cells, and 2) the species differences (between monkeys and rats) of the activity of place cells. In the first fiscal year (1999), we recorded single neuron activity in the monkey hippocampus during the performance of place tasks in which the monkey was or was not required to recognize animal's own location in the environment, and, as a result, we clarified the existence of hippocampal neurons that showed location specific activity only when the monkey recognized the own location; the majority of these neurons lost location specificity in the task that did not require the monkey to recognize own location. In the second fiscal year (2000), we recorded hippocampal neuron activity during the performance of spatial navigation task in freely moving rats, and compared the activity with that during passive trans … More location restraining the rat in a small cage. In this comparison, we again demonstrated that the location specific activity observed in the freely moving condition disappeared when the rat was translocated passively. In the final fiscal year (2001), we developed an experimental system that made it possible to record simultaneously electroencephalograph (EEG) and single neuron activities in freely behaving monkeys, and performed a similar experiment to that of the above rat's study: we recorded EEG and neuron activities in the hippocampus during the performance of spatial navigation task, and compared the activities with those during passive translocation restraining the monkey in a chair. As a result, hippocampal EEG displayed rhythmic slow activity (RSA) at the initiation of locomotion during the free, active spatial navigation while RSA was not observed during the passive translocation. We have recorded activity from 5 hippocampal neurons, and we continues the recording to increase the number of neurons so as to identify response characteristics as neuronal population. In conclusion, we clarified that active locomotion of animals (both monkeys and rats) in the environment, recognizing spatial landmarks in the environment, is important for the representation of "place" in the hippocampus. Less

本研究的目的是：（1）空间任务的移位方式（主动和被动）和认知要求对海马位置细胞活性的影响;（2）位置细胞活性的种属差异（猴和大鼠）。在第一个财政年度（1999年），我们记录了猴子海马中的单个神经元活动，在执行位置任务时，猴子被要求或不被要求识别动物在环境中的位置，结果，我们澄清了海马神经元的存在，只有当猴子识别自己的位置时，才显示位置特异性活动;这些神经元中的大多数在不需要猴子识别自己位置的任务中失去了位置特异性。在第二个财政年度（2000年），我们记录了自由运动大鼠执行空间导航任务时海马神经元的活动，并与被动运动时的活动进行了比较。 ...更多信息将大鼠限制在小笼子中的位置。在这个比较中，我们再次证明了在自由移动条件下观察到的位置特异性活性在大鼠被动移位时消失。在最后一个财政年度（2001年），我们开发了一个实验系统，可以同时记录自由行为猴子的脑电图（EEG）和单个神经元活动，并进行了与上述大鼠研究类似的实验：在空间导航任务的执行过程中，我们记录了脑电图和海马神经元活动，并与被动移位时的活动进行了比较。结果表明，在自由主动空间导航过程中，海马EEG在运动开始时显示出节律性慢活动（RSA），而在被动移位过程中未观察到RSA。我们已经记录了5个海马神经元的活动，我们继续记录以增加神经元的数量，从而识别神经元群体的响应特征。总之，我们澄清了动物（猴子和大鼠）在环境中的主动运动，识别环境中的空间地标，是重要的“地方”在海马体中的代表。少