Coordinate frames for neuronal activities in the supplementary motor area, the premotor area and the primary motor cortex.

辅助运动区、前运动区和初级运动皮层神经元活动的坐标系。

基本信息

批准号：
14580784
负责人：
KAKEI Shinji
金额：
$ 2.69万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14580784/
关键词：
the supplementary motor area the premotor area the primary motor cortex coodinate transformation monkye neuron redording coordinate system 空間関節筋肉運動指令

项目摘要

We recorded the activity of neurons in primary motor cortex (Ml) and ventral premotor cortex (PMv) in a monkey trained to perform a task which dissociates three major coordinate frames of wrist movement: muscle, wrist joint, and an extrinsic coordinate frame. We found three major types of neurons in Ml and PMv. The first type was termed "extrinsic-like." The activity of these neurons appeared to encode the direction of movement in space independent of the patterns of wrist muscle activity or joint movement that produced the movements. The second type was termed "extrinsic-like with gain modulation". The activity of these neurons appeared to encode the direction of movement in space, but the magnitude (gain) of neuronal activity depended on the posture of the forearm. The third type was termed "muscle-like" since their activity co-varied with muscle activity. The great majority of the directionally-tuned neurons in the PMv were classified as "extrinsic-like" (48/59, 81 %). A smaller group was classified as "extrinsic-like with gain modulation" (7/59, 12%). In Ml, the three types of neurons were more equally represented. Our results raise the possibility that cortical processing between Ml and PMv may contribute to a sensorimotor transformation between extrinsic and intrinsic coordinate frames. Recent modeling studies have demonstrated the computational plausibility of such a process.

我们记录了一只经过训练的猴子中神经元在原发运动皮层（ML）和腹侧前皮层（PMV）中的活性，以执行腕部运动的三个主要坐标框架：肌肉，腕关节和外部坐标框架。我们在ML和PMV中发现了三种主要类型的神经元。第一种类型被称为“外在的”。这些神经元的活性似乎与腕部肌肉活动或关节运动产生运动的模式无关。第二种类型称为“具有增益调制的外在样本”。这些神经元的活性似乎编码了空间中运动的方向，但是神经元活性的大小（增益）取决于前臂的姿势。第三种类型被称为“肌肉样”，因为它们的活性与肌肉活性共同变化。 PMV中绝大多数定向调整的神经元被归类为“外部样式”（48/59，81％）。一组较小的组被归类为“具有增益调制的外部样本”（7/59，12％）。在ML中，三种类型的神经元具有更同样的代表。我们的结果增加了ML和PMV之间的皮质处理可能有助于外在和内在坐标框架之间的感觉运动转化。最近的建模研究表明，这种过程的计算合理性。