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Two dimensional crystallization of ferritin protein for nano-scale process in semiconductor fabrication

用于半导体制造纳米级工艺的铁蛋白二维结晶

基本信息

批准号：
15360013
负责人：
URAOKA Yukiharu
金额：
$ 8.64万
依托单位：
Nara Institute of Science and Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

Development of biotechnology has been remarkable, which enables us to fabricate nanoscale structures using biomolecules as nanoblocks. A combination of biotechnology and semiconductor technology is emerging as a promising candidate for enabling a breakthrough in the fabrication of advanced electronic devices. The main features of biotechnology from a nanotechnology point of view are as follows : Size distribution is extremely small on the molecular scale. Biomolecules can form nanostructures in a self-assembling manner, which is an essential part of the bottom-up fabrication technology. Protein has the ability to biomineralize inorganic materials at its surface. Utilizing these characteristics, we propose a novel bottom-up method for fabricating nanostructure with a very small size distribution.We have a floating nano-dot gate metal-oxide-semiconductor field effect transistor(MOSFET). The floating nano-dots gate MOSFET is expected to be promising candidate component for next-generation memory such as flash memory. It is required that the floating nanod-dots have a small size distribution and should take the form of a high-density monolayer. We adopted the cage-shaped protein ferritin to satisfy these requirements. Ferritin has a protein shell, its outer and inner diameters are 12 nm and 7 nm, respectively, and it has fairly high thermal and pH stabilities compared with other proteins. The inner cavity can accommodate an iron oxide core (5Fe_2O_3・9H_2O). Therefore, iron oxide nano-dots with small size distribution can be artificially synthesized with ferritin molecules. It has also demonstrated that ferritin molecules can form a large two-dimensional crystal that is a high-density monolayer. Combining these characteristics, we fabricated a monolayer of ferritin with iron oxide cores.

生物技术的发展令人瞩目，这使我们能够利用生物分子作为纳米块来制造纳米级结构。生物技术和半导体技术的结合正在成为实现先进电子设备制造突破的有希望的候选者。从纳米技术的角度来看，生物技术的主要特征如下：分子尺度上的尺寸分布极小。生物分子可以以自组装的方式形成纳米结构，这是自下而上制造技术的重要组成部分。蛋白质具有在其表面生物矿化无机材料的能力。利用这些特性，我们提出了一种新颖的自下而上的方法来制造具有非常小尺寸分布的纳米结构。我们有一个浮动纳米点栅极金属氧化物半导体场效应晶体管（MOSFET）。浮动纳米点栅极MOSFET有望成为闪存等下一代存储器的有希望的候选元件。要求浮动纳米点具有小尺寸分布并且应采取高密度单层的形式。我们采用笼状铁蛋白来满足这些要求。铁蛋白有一个蛋白质外壳，其外径和内径分别为12 nm和7 nm，与其他蛋白质相比，它具有相当高的热稳定性和pH稳定性。内腔可容纳氧化铁芯（5Fe_2O_3·9H_2O）。因此，可以用铁蛋白分子人工合成具有小尺寸分布的氧化铁纳米点。它还证明铁蛋白分子可以形成大的二维晶体，即高密度单层。结合这些特性，我们制造了具有氧化铁核的单层铁蛋白。