Two dimensional crystallization of ferritin protein for nano-scale process in semiconductor fabrication

生物技术的发展是显而易见的，它使我们能够利用纳米锁制造纳米尺度结构。生物技术和半导体技术的结合正在兴起，作为一个被提名的候选人，以在先进电子设备的制造中实现一个突破。生物技术的主要特征来自纳米技术的观点点如下：分子尺度上的分布非常小。生物分子可以在自我组装的标记中形成纳米结构，它是自下而上制造技术的重要部分。蛋白质具有在其表面上生物质化非有机材料的能力。利用这些特性，我们提出了一种新颖的自下而上的方法，用一个非常小的尺寸分布制造纳米结构，我们有一个浮动的纳米点金属氧化物半导体场效应晶体管（MOSFET）。浮动纳米点门MOSFET是预期被提名为下一代存储器这样的闪存的候选组件。这是必要的，因为浮动的纳米点有一个小尺寸的分布，应该采用高密度单体的形式。我们已经接受了笼形蛋白铁蛋白来满足这些要求。Ferritin有一个蛋白质外壳，它的外和内二极管分别为12纳米和7纳米，相当高的热和pH稳定性与其他蛋白质相比较。内部洞穴可以适应氧化铁核心（5Fe_2O_3·9H_2O）。因此，用小尺寸分布的铁氧化物纳米点可以用铁蛋白分子进行人工合成。它也被证明是因为铁蛋白分子可以形成一个大的两尺寸晶体，因为它是一个高密度单体。将这些特征结合起来，我们制造了一种含铁氧化物核心的铁蛋白单体。

Development of biotechnology has been remarkable, which enables us to fabricate nanoscale structures using biomolecules as nanoblocks. A combination of biotechnology and semiconductor technology is emerging as a promising candidate for enabling a breakthrough in the fabrication of advanced electronic devices. The main features of biotechnology from a nanotechnology point of view are as follows : Size distribution is extremely small on the molecular scale. Biomolecules can form nanostructures in a self-assembling manner, which is an essential part of the bottom-up fabrication technology. Protein has the ability to biomineralize inorganic materials at its surface. Utilizing these characteristics, we propose a novel bottom-up method for fabricating nanostructure with a very small size distribution.We have a floating nano-dot gate metal-oxide-semiconductor field effect transistor(MOSFET). The floating nano-dots gate MOSFET is expected to be promising candidate component for next-generation memory such as flash memory. It is required that the floating nanod-dots have a small size distribution and should take the form of a high-density monolayer. We adopted the cage-shaped protein ferritin to satisfy these requirements. Ferritin has a protein shell, its outer and inner diameters are 12 nm and 7 nm, respectively, and it has fairly high thermal and pH stabilities compared with other proteins. The inner cavity can accommodate an iron oxide core (5Fe_2O_3・9H_2O). Therefore, iron oxide nano-dots with small size distribution can be artificially synthesized with ferritin molecules. It has also demonstrated that ferritin molecules can form a large two-dimensional crystal that is a high-density monolayer. Combining these characteristics, we fabricated a monolayer of ferritin with iron oxide cores.