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Interrelationship between the cortical and amygdaloid outputs within the forebrain region in the control of the autonomic function.

前脑区域皮质和杏仁输出之间在控制自主功能方面的相互关系。

基本信息

批准号：
15500214
负责人：
TSUMORI Toshiko
金额：
$ 2.43万
依托单位：
Shimane University (2004)Shimane Medical University (2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500214/
关键词：
insular cortex infralimbic cortex amygdala lateral hypothalamus nucleus tractus solitarii rat

项目摘要

We demonstrated possible pathways from the infralimbic cortex(ILC), the insular cortex(IC) and the central nucleus of the amygdala(ACe), to the nucleus of the solitary tract(NST) via the lateral hypothalamus(LH) using combined anterograde and retrograde tracing method. Prominent overlapping distributions of these cortical or amygdaloid fibers and NST-projecting neurons were observed in the lateralmost part of the posterior LH. In this region, both cortical fibers formed asymmetrical synapses with dendrites and spines of the NST-projecting neurons, whereas the amygdaloid fibers made symmetrical synapses with dendrites and cell bodies of the NST-projecting neurons. We also revealed the synaptic organization between and among the fibers originating from the IC and ACe, and the LH neurons using double anterograde labeling. Prominent overlapping distributions of the IC and ACe fibers were found in the lateralmost part of the posterior LH. In this area, some of single dendrite or spine received convergent synaptic inputs from both sets of terminals. Using anterograde tracing combined with immunohistochemistry for GABA, we further showed that most of the amygdaloid fibers were GABAergic and that they contained not only clear vesicles but also dense-cored vesicles, suggesting the co-localization of GABA and peptides. Taken together, these results suggest possible pathways from the ILC, IC and ACe to the NST via the LH. Moreover, excitatory inputs from the ILC and IC, and inhibitory inputs from the Ace might be integrated in the NST-projecting neurons in the LH for the control of the autonomic function

应用顺行和逆行结合的方法，研究了从边缘下皮层（ILC）、岛叶皮层（IC）和杏仁中央核（ACe）经外侧下丘脑（LH）到孤束核（NST）的可能通路。这些皮质或杏仁纤维和NST投射神经元的突出重叠分布在LH后部的lateralmost部分。在这一区域，皮质纤维与NST投射神经元的树突和棘形成不对称的突触，而杏仁纤维与NST投射神经元的树突和胞体形成对称的突触。我们还揭示了来自IC和ACe的纤维之间的突触组织，和LH神经元使用双顺行标记。IC和ACe纤维在LH后部的近侧部有明显的重叠分布。在该区域，一些单个树突或棘接受来自两组终末的会聚性突触输入。用顺行追踪结合免疫组化的GABA，我们进一步表明，大多数的杏仁核纤维的GABA能，它们不仅包含明确的囊泡，但也致密的核心囊泡，这表明GABA和肽的共定位。综上所述，这些结果表明可能的途径，从ILC，IC和ACe的NST通过LH。此外，来自ILC和IC的兴奋性输入以及来自Ace的抑制性输入可能整合到LH的NST投射神经元中，以控制自主神经功能