Morphological experiments of the control of jaw movements in the forebrain

前脑控制下颌运动的形态学实验

• 批准号: 09832009
• 负责人: TSUMORI Toshiko
• 金额: $ 1.92万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09832009/
• 关键词: substantia nigra pars reticulata; parafascicular thalamic nucleus; striatum; lateral agranular cortex; 外側無顆粒性皮質; 大脳皮質; 大脳基底核; 視床; 黒質; 顎運動

We have already indicated that the dorsolateral part of the substabtia nigra pars reticulata (SNr), which is one of the major output nuclei of the basal ganglia, plays an important role in the control of jaw movement. The rostroventral part of the lateral agranular cortex (AGi) and the ventrolateral part of the striatum have been known as the area involved in the control of orofacial movement, In the present study, we examined the possible pathways from the dorsolateral part of the SNr to the rostroventral part of the AGl and the ventrolateral part of the striatum relayed by the thalamus using a combined anterograde and retrograde tracing technique.We first showed that the dorsolateral part of the SNr sent projection fibers to the ventrolateral part of the parafascicular thalamic nucleus (PE). Secondly, we indicated the overlapping distributions of the nigral fibers and the PF neurons projecting to the rostroventral part of the AGl or to the ventrolateral part of the striatum in the ventrolateral part of the PF.This part of the PF contained not only some neurons projecting to the rostroventral part of the AGl, but also many neurons projecting to the ventrolateral part of the striatum. The nigral axon terminals made symmetrical synaptic contacts with the soma and dendrites of the PF neurons projecting to the AGl or to the striatum. Thus, the SNr-PF-AGl and SNr-PF-striatal pathways revealed by the present study may be involved in the control mechanism of orofacial motor functions.

我们已经指出，黑下网状部（SNr）的背外侧部分是基底神经节的主要输出核之一，在控制下颌运动中发挥着重要作用。外侧无颗粒皮质（AGi）的口腹侧部分和纹状体的腹外侧部分被认为是参与控制口面部运动的区域。在本研究中，我们使用组合顺行检查了从 SNr 的背外侧部分到 AGl 的口腹部分和纹状体腹外侧部分的可能路径。 我们首先表明SNr的背外侧部分将投射纤维发送到束旁丘脑核（PE）的腹外侧部分。其次，我们指出了黑质纤维和投射到AGl的前腹侧部分或PF的腹外侧部分的纹状体的腹外侧部分的黑质纤维和PF神经元的重叠分布。这部分PF不仅包含一些投射到AGl的前腹侧部分的神经元，而且还包含许多投射到AGl的腹外侧部分的神经元。 纹状体。黑质轴突末端与投射到 AG1 或纹状体的 PF 神经元的胞体和树突形成对称的突触接触。因此，本研究揭示的SNr-PF-AGl和SNr-PF-纹状体通路可能参与口面部运动功能的控制机制。

项目成果

Toshiko Tsumori: "Synaptic organization between the nigral fibers and the parafascicular halamic neurons projecting to the cortex and the striatum in the rat." Acta Anatomica Nipponica. (in press).

Toshiko Tsumori：“黑质纤维和束旁丘脑神经元之间的突触组织投射到大鼠的皮质和纹状体。”

Toshiko Tsumori: "Demonstration of the corticotectobulbar pathway from the orofacial motor cortex to the parvicellular reticular formation in the rat" Brain Research. 755・1. 151-155 (1997)

Toshiko Tsumori：“大鼠中从口面运动皮层到小细胞网状结构的皮质球脑通路的演示”Brain Research 755・1（1997）。

Yukihiko Yasui: "Nigral axon terminals are in contact with parvicellular reticular neurons which project to the motor trigeminal nucleus in the rat." Brain Research. 755・1/2. 219-224 (1997)

Yukihiko Yasui：“黑质轴突末端与投射到大鼠运动三叉神经核的小细胞网状神经元接触。” 755・1/2（1997）。

Yukihiko Yasui: "Tectal projections to the parvicellular reticular formation and the upper cervical spinal cord in the rat,with special reference to axon collateral innervation." Brain Research. 804. 149-154 (1998)

Yukihiko Yasui：“大鼠小细胞网状结构和上颈脊髓的顶盖投影，特别是轴突侧支神经支配。”

Yukihiko Yasui: "Nigral axon terminals are in contact with parvicellular reticular neurons which project to the motor trigeminal nucleus in the rat" Brain Research. 775・1/2. 219-224 (1997)

Yukihiko Yasui：“黑质轴突末端与投射到大鼠运动三叉神经核的小细胞网状神经元接触”Brain Research 775·1/2（1997）。