Morphological analysis for the relationship between the leptin-melanocortin control system and the vagus nerve in feeding.

瘦素-黑皮质素控制系统与摄食中迷走神经关系的形态学分析。

• 批准号: 23500411
• 负责人: TSUMORI Toshiko
• 金额: $ 3.41万
• 依托单位: Prefectural University of Hiroshima (2013)Shimane University (2011-2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500411/
• 关键词: メラノコルチン４受容体; 摂食行動; エネルギーバランス; 迷走神経背側運動核; 迷走神経; 膵内神経節; 壁内神経節; 遺伝子導入マウス; melanocortin-4 receptor; vagus nerve; nodose ganglion; GFP; mouse; pancreas; islet; DMV; stomach; duodenum

The central melanocortin system including melanocortin-4 receptor (MC4R) plays an important role not only in the control of feeding and energy expenditure but also in glucose/insulin homeostasis. Using a transgenic mouse model in which green fluorescent protein is produced under the control of the MC4R promoter, we found that the dorsal motor nucleus of the vagus nerve contains many MC4R-expressing neurons, some of which made synapses with the postganglionic cells in the intramural ganglia of the stomach and duodenum, as well as in the intrapancreatic ganglia. These results suggested that projection fibers from the MC4-R-expressing DMV neurons to the enteric and intrapancreatic ganglia may be closely related to the control of gastrointestinal and pancreatic functions.

中枢黑皮质素系统包括黑皮质素-4受体（MC 4 R），不仅在控制摄食和能量消耗方面起重要作用，而且在葡萄糖/胰岛素稳态中起重要作用。使用转基因小鼠模型，其中绿色荧光蛋白的MC 4 R启动子的控制下产生的，我们发现，迷走神经的背侧运动核包含许多MC 4 R表达神经元，其中一些作出突触与节后细胞的壁内神经节的胃和十二指肠，以及在胰内神经节。这些结果表明，从MC 4-R表达DMV神经元到肠和胰腺内神经节的投射纤维可能与胃肠和胰腺功能的控制密切相关。

项目成果

Melanocortin-4 receptor expressing neurons in the geniculate and petrosal ganglia send their fibers to the tongue taste bud cells

膝状体和岩神经节中表达 Melanocortin-4 受体的神经元将其纤维发送到舌头味蕾细胞

• 发表时间: 2014
• 作者: 津森登志子;岡 達郎;横田茂文;安井幸彦
• 通讯作者: 安井幸彦

Nodose ganglion cells expressing melanocortin-4 receptor send their fibers to the pancreatic islets in the mouse.

表达黑皮质素 4 受体的结状神经节细胞将其纤维发送至小鼠的胰岛。

• 作者: Nakamuta S.;et al;Akira Sakakibara;榊原明;津森登志子・岡 達郎・牛 建国・安井幸彦
• 通讯作者: 津森登志子・岡 達郎・牛 建国・安井幸彦

Pancreatic islets cells receive axon terminals from melanocortin-4 receptor-expressing nodose ganglion cells in the mouse

小鼠胰岛细胞接收来自表达黑皮质素 4 受体的结状神经节细胞的轴突末端

• 发表时间: 2013
• 作者: 津森登志子;岡 達郎;横田茂文;安井幸彦
• 通讯作者: 安井幸彦

Synaptic organization between melanocortin-4 receptor-expressing neurons in the dorsal motor nucleus of the vagus nerve and enteric ganglia neurons in the mouse

小鼠迷走神经背运动核中表达黑皮质素 4 受体的神经元与肠神经节神经元之间的突触组织

• 发表时间: 2011
• 作者: 津森登志子;岡 達郎;牛 建国;安井幸彦
• 通讯作者: 安井幸彦

Tongue taste buds receive nerve terminals originating from melanocortin-4 receptor expressing neurons in the mouse geniculate and petrosal ganglia

舌头味蕾接收源自小鼠膝状体和岩神经节中表达黑皮质素-4受体的神经元的神经末梢

• 发表时间: 2013
• 作者: 津森登志子;岡 達郎;牛 建国;安井幸彦
• 通讯作者: 安井幸彦