Functional roles of cortico-basal gangila loops in conditional motor learning
皮质基底神经节环在条件运动学习中的功能作用
基本信息
- 批准号:15500290
- 负责人:
- 金额:$ 2.11万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to examine functional roles of the prefrontal cortex in arbitrary visuomotor association, we recorded neuronal activity in the medial prefrontal cortex, area 9m, of a behaving monkey during conditional visuomotor learning. The monkey was presented a cueing visual stimulus, and following a delay period required to push, pull, or turn a manipulator according to the cue. Under the control condition three cues instructed the monkey to the three responses in a block of trials. After a few months of training the animal was familiar with these associations. Under the learning condition, two of the three familiar cues and one novel cue were presented in a block. The monkey needed to learn a new cue-response association by trial and error. Area 9m neurons responded to cue presentation. The Cue responses changed whether a cue was familiar or novel. A group of area 9m neurons responded to a novel cue, bur not to familiar ones. Other group of neurons responded to familiar cues, but not to a novel one. In a subgroup of these familiar cue-selective neurons the cue responses were enhanced under the learning condition compared to the control condition. These results suggest that cue familiarity is represented in area 9m activity and/or that the activity may be involved in action selection during the arbitrary visuomotor association learning.
为了研究前额叶皮层在任意视觉运动联想中的功能作用,我们记录了猴子在条件视觉运动学习过程中前额叶皮层内侧9m区域的神经元活动。研究人员给猴子提供了一个视觉刺激提示,并在一段时间后根据提示推、拉或转动操纵器。在控制条件下,三个线索指示猴子在一组试验中做出三种反应。经过几个月的训练,这只动物熟悉了这些联系。在学习条件下,三个熟悉线索中的两个和一个新线索被呈现在一个块中。猴子需要通过试错来学习新的线索反应关联。900万区域的神经元对提示有反应。提示反应会随着熟悉或陌生的提示而改变。一组面积达900万的神经元对新线索做出反应,但对熟悉的线索却没有反应。另一组神经元对熟悉的线索有反应,但对新的线索没有反应。在这些熟悉的线索选择神经元的一个亚组中,学习条件下的线索反应比控制条件下的线索反应增强。这些结果表明,提示熟悉度在9m区域的活动中表现出来,并且/或者该活动可能参与了任意视觉运动联想学习过程中的动作选择。
项目成果
期刊论文数量(23)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Neuron classification based on temporal firing patterns by the dynamical analysis with changing time resolution
通过时间分辨率变化的动态分析,基于时间放电模式的神经元分类
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Oshio K;Yamada S;Nakashima M
- 通讯作者:Nakashima M
Relations of magnetically evoked EMGs and the spinal vascular lesions in M-SHRSP
磁诱发肌电图与M-SHRSP脊髓血管病变的关系
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Chiba A;Oshio K;Murata A;Inase M
- 通讯作者:Inase M
Neuronal activity for duration discrimination in monkey prefrontal cortex
猴子前额皮质持续时间辨别的神经元活动
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Oshio K;Chiba A;Inase M
- 通讯作者:Inase M
Organization of prefrontal outflow toward frontal motor-related areas in macaque monkeys
猕猴额叶运动相关区域前额叶流出的组织
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Takeda M;Nambu A;Hatanaka N;Tachibana Y;Miyachi S;Taira M;Inase M
- 通讯作者:Inase M
Effects of static magnetic field for muscular contraction by pain
静磁场对疼痛引起的肌肉收缩的影响
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Chiba A;Oshio K;Inase M
- 通讯作者:Inase M
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
INASE Masahiko其他文献
INASE Masahiko的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('INASE Masahiko', 18)}}的其他基金
Neuronal activity underlying time perception and time regeneration in the higher brain
高级大脑中时间感知和时间再生的神经元活动
- 批准号:
17K01994 - 财政年份:2017
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Neuronal mechanisms for interval timing in cerebral cortex and basal ganglia
大脑皮层和基底神经节间隔计时的神经机制
- 批准号:
26350996 - 财政年份:2014
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Neural mechanism for temporal discrimination of visual and auditory sensory stimuli
视觉和听觉刺激的时间辨别的神经机制
- 批准号:
21500376 - 财政年份:2009
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Temporal Information Processing in Prefrontal-Basal Ganglia Circuit
前额叶-基底神经节环路的时间信息处理
- 批准号:
18500314 - 财政年份:2006
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Functional organization of the prefrontal cortex
前额皮质的功能组织
- 批准号:
12680787 - 财政年份:2000
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
相似海外基金
Evolutionary mechanisms of neoteny and enlargement of the human cerebral cortex
人类大脑皮层幼态持续和扩大的进化机制
- 批准号:
EP/Z000718/1 - 财政年份:2024
- 资助金额:
$ 2.11万 - 项目类别:
Research Grant
Impacts of Species-dependent Long Non-coding RNA Expression on Formation of Phenotypic Diversity in Mammalian Cerebral Cortex
物种依赖性长非编码RNA表达对哺乳动物大脑皮层表型多样性形成的影响
- 批准号:
23KJ1627 - 财政年份:2023
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Chemical Genetic Dissection of SWI/SNF Chromatin Remodeling Complex Functions in Cerebral Cortex Development
大脑皮层发育中 SWI/SNF 染色质重塑复杂功能的化学遗传学解析
- 批准号:
10660367 - 财政年份:2023
- 资助金额:
$ 2.11万 - 项目类别:
Evolution of the Cerebral Cortex by Experimental Manipulation Using Cell Cycle Withdrawal Delay
利用细胞周期撤回延迟进行实验操作大脑皮层的进化
- 批准号:
23K18169 - 财政年份:2023
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Memory and Recognition Integration Model Inspired by Hippocampus and Cerebral Cortex
受海马体和大脑皮层启发的记忆和识别整合模型
- 批准号:
23K11247 - 财政年份:2023
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Manipulation of neuron identity towards in-vivo circuit reprogramming in the cerebral cortex
操纵神经元身份以实现大脑皮层体内电路重编程
- 批准号:
10755203 - 财政年份:2023
- 资助金额:
$ 2.11万 - 项目类别:
Decoding circuit neural activity in peripheral nerve and cerebral cortex with Optical Coherence Tomography of structure and birefringence
利用光学相干断层扫描结构和双折射解码周围神经和大脑皮层的回路神经活动
- 批准号:
2723225 - 财政年份:2022
- 资助金额:
$ 2.11万 - 项目类别:
Studentship
Effect of vitamin C on neural development of the cerebral cortex.
维生素C对大脑皮层神经发育的影响。
- 批准号:
22K11775 - 财政年份:2022
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortex
系统鉴定增强剂以靶向大脑皮层兴奋性和抑制性神经元细胞类型的广度
- 批准号:
10512459 - 财政年份:2022
- 资助金额:
$ 2.11万 - 项目类别:
The role of retinoic acid signaling in patterning the human cerebral cortex
视黄酸信号在人类大脑皮层模式化中的作用
- 批准号:
10590628 - 财政年份:2022
- 资助金额:
$ 2.11万 - 项目类别: