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Temporal Information Processing in Prefrontal-Basal Ganglia Circuit

前额叶-基底神经节环路的时间信息处理

基本信息

批准号：
18500314
负责人：
INASE Masahiko
金额：
$ 2.38万
依托单位：
Kinki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

We have been conducting neurophysiological experiments to reveal neuronal mechanisms for temporal information processing in the prefrontal-basal ganglia circuit. Monkeys were trained to perform a duration discrimination task. In the task, two visual cues were presented successively in different duration (0.2〜1.6 sec). Each cue presentation was followed by a 1-sec delay period. The subjects were instructed to choose a longer presented cue after the second delay period. Single-unit activity was recorded from the prefrontal cortex and the striatum while the monkeys were performing the task.Prefrontal neurons showed phasic activity during the first cue period. The activity had peak time around 800ms that was close to the midpoint between long and short cue duration. This activity might have functioned for filtering cue duration to discriminate between long and short cues. In the first delay period prefrontal neurons exhibited differential activity following long and short cues. In the neurons with preference for long cues the delay activity after longer cues was uniformly high regardless of cue duration, but that after shorter cues was uniformly low. This binary change in the delay activity indicates that the prefrontal cortex could represent cue duration categorically as long or short. Striatal neurons phasically responded during the first and second delay periods. Responses during the first delay period changed depending on the first cue duration. Activity of populations of these neurons correlated with the first cue duration positively or negatively. Responses during the second delay period differed between long-short and short-long trials. These findings suggest that striatal neurons could encode cue duration with monotonically changing responses and discrimination results between the two cue durations.

我们一直在进行神经生理学实验，以揭示额前-基底神经节回路中时间信息处理的神经机制。训练猴子执行持续时间辨别任务。在任务中，两个视觉线索连续呈现在不同的持续时间（0.2〜1.6秒）。每个提示呈现之后是1秒的延迟期。在第二个延迟期后，受试者被要求选择一个更长的提示。当猴子执行任务时，记录了前额叶皮层和纹状体的单个单位活动。前额叶神经元在第一个提示期表现出阶段性活动。该活动在800 ms左右具有峰值时间，该峰值时间接近长线索持续时间和短线索持续时间之间的中点。这种活动可能起到过滤线索持续时间的作用，以区分长线索和短线索。在第一个延迟期，前额叶神经元表现出不同的活动后，长和短的线索。在神经元的偏好长线索的延迟活动后，较长的线索是一致的高，无论线索的持续时间，但较短的线索后是一致的低。这种延迟活动的二元变化表明，前额叶皮层可以将线索持续时间分类为长或短。纹状体神经元在第一和第二延迟期阶段性反应。第一延迟时段期间的响应根据第一提示持续时间而改变。这些神经元群体的活动与第一提示持续时间呈正或负相关。在第二个延迟期的反应不同之间的长短和短-长试验。这些结果表明，纹状体神经元可以编码提示时长与单调变化的反应和区分结果之间的两个提示时长。