权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Functional organization of the prefrontal cortex

前额皮质的功能组织

基本信息

批准号：
12680787
负责人：
INASE Masahiko
金额：
$ 1.73万
依托单位：
Kinki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

The prefrontal association cortex is the highest brain center related to perception, memory intelligence, planning, and so on. The cortex is further divided into many areas. We have been examining input-output arrangement of these areas to elucidate functional organization of the frontal cortex.In the present project we investigated the organization of cingulate motor areas inputs to the primate basal ganglia. The cingulate motor areas reside within regions lining the cingulate sulcus and are divided into rostral and caudal parts. Recent studies suggest that the rostral and caudal cingulate motor areas participate in distinct aspects of motor function : The former plays a role in higher-order cognitive control of movements, whereas the latter is more directly involved in their execution. Identified forelimb representations of the rostral and caudal cingulate motor areas were injected with different anterograde tracers, and the distribution patterns of labeled 'terminals were analyzed i … More n the striatum and the subthalamic nucleus. Corticostriatal inputs from the rostral and caudal cingulate motor areas were located within the rostral striatum, with the highest density in the striatal cell bridges or the ventrolateral portions of the putamen, respectively. There was no substantial overlap between these input zones. Similarly, a certain segregation of input zones from the rostral and caudal cingulate motor areas occurred along the mediolateral axis of the subthalamic nucleus. It has also been revealed that corticostriatal and corticosubthalamic input zones from the rostral cingulate motor area considerably overlapped those from the presupplementary motor area, while the input zones from the caudal cingulate motor area displayed a large overlap with those from the primary motor cortex. The present results indicate that a parallel design essentially underlies motor information processing in the cortico-basal ganglia loop derived from the rostral and caudal cingulate motor areas. Less

前额叶联合皮层是与感知、记忆、智力、计划等有关的最高脑中枢，皮层又分为许多区域。我们一直在研究这些区域的输入输出安排，以阐明额叶皮层的功能组织。在本项目中，我们调查了扣带运动区的组织输入到灵长类动物基底神经节。扣带运动区位于扣带沟的内衬区域内，并分为喙部和尾部。最近的研究表明，头侧和尾侧扣带运动区参与运动功能的不同方面：前者在运动的高阶认知控制中发挥作用，而后者更直接地参与运动的执行。用不同的顺行示踪剂注入已确定的扣带运动区头端和尾端的前肢代表，并分析标记终末的分布模式。 ...更多信息在纹状体和丘脑底核。皮质纹状体输入的喙和尾扣带回运动区位于喙纹状体内，密度最高的纹状体细胞桥或腹外侧部分的壳核，分别。这些输入区之间没有实质性重叠。同样，输入区与扣带运动区的嘴侧和尾侧也发生了一定的分离，沿着丘脑底核的中外侧轴。它也被发现，皮质纹状体和皮质下丘脑的输入区从喙扣带运动区相当大的重叠，从presupplementary运动区，而输入区从尾扣带运动区显示了很大的重叠与那些从初级运动皮层。目前的研究结果表明，一个平行的设计基本上是运动信息处理的皮质基底神经节回路来自喙和尾扣带运动区。少