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STUDY ON THE BENEFICIAL EFFECT OF ALLERGY LABELLING SYSTEM OF PROESSED FOODS ON THE QUALITY OF LIFE OF CHILDREN WITH FOOD ALLERGY AND ITS CLINICAL EVALUATION

加工食品过敏标签制度对食物过敏儿童生活质量的有益影响及其临床评价

基本信息

批准号：
15500557
负责人：
ITO Setsuko
金额：
$ 2.37万
依托单位：
DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

The beneficial effect of allergy labeling system of specified ingredients in the processed foods on the quality of life (QOL) of children with food allergy was studied using questionnaire for parents, pediatricians, nursing staff and dietitian. QOL of infants with food allergy was considered to have improved thanks to allergy labeling system only by 57.4% of their parents, 59.1% of dietitians, 45.7% of pediatricians, 38.5% of nursing staffs. More than half of them had difficulty in understanding the alternative declaration of specified ingredients.20.0% of pediatricians had experienced patients who demonstrated hypersensitivity reaction after intake of processed food with no labeling about allergen concerned with the reaction. There were foods without labeling in which more than 10μg/g of allergen were contained and foods in which the concentration of allergen was less than 10μg/g, but the amount of allergen exceeded 200μg as a meal: enough amount to cause allergic reaction in highly sensitized infants.We could establish ELISA system to assay the amount of egg antigen in foods with sensitivity and specificity compatible with commercially available specified measuring kit for ovalbumin. This system was not suitable for the detection of egg protein as an ingredient but was suitable to evaluate reduction of allergenicity compatible with clinical observation. Studies on the basophil histamine release test revealed that the amount of several ng of allergen was enough to release histamine from basophils separated from peripheral blood, indicating the possibility of necessity of labeling of smaller amount of specified ingredients than the existing system.These results were included n the dietary counseling guideline for clinical use.

通过对家长、儿科医生、护理人员和营养师的问卷调查，探讨加工食品中特定成分过敏标签制度对食物过敏儿童生活质量的有利影响。57.4%的父母、59.1%的营养师、45.7%的儿科医生、38.5%的护理人员认为食物过敏婴儿的生活质量得到了改善。20.0%的儿科医生曾有患者在进食加工食品后表现出过敏反应，但没有与该反应有关的过敏原标签。有些食品中的过敏原含量超过10μg/g，有些食品中的过敏原浓度低于10μg/g，但每餐中的过敏原含量超过200μg：足以引起高度致敏的婴儿的过敏反应。我们可以建立与市售卵清蛋白专用检测试剂盒兼容的敏感性和特异性检测食品中鸡蛋抗原含量的ELISA法。该系统不适用于作为成分的鸡蛋蛋白的检测，但适用于评价与临床观察相一致的减敏效果。对嗜碱性粒细胞组胺释放试验的研究表明，几ng的过敏原足以从外周血中分离出的嗜碱性粒细胞中释放组胺，这表明有必要对比现有系统更少的特定成分进行标记。这些结果包括在临床使用的饮食咨询指南中。

项目成果

期刊论文数量（30）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

新しい診断と治療のABC 26/免疫 4 食物アレルギー

新诊疗基础知识26/免疫学4 食物过敏

DOI：
发表时间：
2005
期刊：
影响因子：
0
作者：
Masanobu Hibi;Satoshi Hachimura;Wataru Ise;Ayuko Sato;Tadashi Yoshida;Tsuyoshi Takayama;Kastumi Sasaki;Takashi Senga;Shuichi Hashizume;Mamoru Totsuka;Shuichi Kaminogawa.;Mamoru Totsuka. 戸塚護;戸塚護(分担執筆)
通讯作者：
戸塚護(分担執筆)

食物アレルギーの自然歴

食物过敏的自然史