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Development of Effective Analytical System for Studies on Human Exposure to Toxic Elements Caused by Environmental Pollution

开发有效的分析系统来研究人类暴露于环境污染引起的有毒元素的情况

基本信息

批准号：
15510029
负责人：
SERA Koichiro
金额：
$ 1.02万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

In 2003 fiscal year, a standard-free method for untreated nail samples was established, and it has been applied to studies on human exposure to mercury and arsenic in various countries such as Philippines and Mongolia. Further, we developed a method of quantitative analysis of fluorine making use of the "Three-detector measuring system" which we established two years ago. This method allows us to discuss correlation between fluorine and other toxic elements such as arsenic and manganese. This method has been applied to the samples taken from Chinese people living in contaminated areas, and the correlation among fluorine, manganese and arsenic were confirmed. This method has been further applied to plants, sea foods, fungi, and tap waters, and becomes a powerful method in the fields of environmental science and sitology etc.In 2004 fiscal year, a new external multi-channel analyzer was purchased and the system for effective analyses of spectrum data from three detectors was established. It has been applied to more than 2000 hairs, urines and nails taken from people living in contaminated areas in China, Monogolia and Kazakhstan etc. Furthermore, Standard-free methods for spinal fluid, saliva, sweat, tear and snivel have been developed and it made it possible to quantitatively analyze extremely small amount of these samples. We are planning to apply these methods to studies on human exposure to toxic elements in many countries in Asia.

2003财年，建立了针对未经处理的指甲样品的无标方法，并应用于菲律宾、蒙古等多个国家的人体汞和砷暴露研究。此外，我们还利用两年前建立的“三检测器测量系统”开发了氟定量分析方法。这种方法使我们能够讨论氟与砷和锰等其他有毒元素之间的相关性。该方法已应用于生活在污染地区的中国人的样本中，证实了氟、锰和砷之间的相关性。该方法已进一步应用于植物、海鲜、真菌、自来水等领域，成为环境科学、土壤学等领域的有力方法。2004财年，购买了新的外置多通道分析仪，建立了对三个探测器的光谱数据进行有效分析的系统。该方法已应用于中国、蒙古、哈萨克斯坦等地污染地区居民的2000多根毛发、尿液和指甲。此外，还开发了脊髓液、唾液、汗液、眼泪和鼻涕的无标准方法，使得对极少量的这些样本进行定量分析成为可能。我们计划将这些方法应用于亚洲许多国家人体接触有毒元素的研究。