Preparation of fine ferrite powder for local thermal coagulation technique under alternating magnetic field

交变磁场局部热凝技术制备铁氧体细粉

• 批准号: 15560610
• 负责人: AONO Hiromichi
• 金额: $ 2.43万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15560610/
• 关键词: Ferrite; Alternating magnetic field; Thermal coagulation; Mg_<1-x>Ca_xFe_2O_4; Fine powder; Reverse coprecipitation method; Magnetite; Mg_<1-x>Ca_xFe_2O_4; Mg_<1-x>Ca_xFe_O_4; グリコサーマル法

Selection of ferrite powder and suitable frequency were carried out to realize a thermal coagulation technique in which tumors are locally heated to 60-80℃ by an application of alternating magnetic field from external coils after they are stuffed with ferrite powder. Various ferrite powders were heated by an alternating magnetic field in 80kHz-399kHz. In this frequency range, the largest increase in temperature (ΔT) was obtained for the MgFe_2O_4 in all the samples examined. The ΔT value was almost proportional to the applied power and the weight of the powder. The heating ability for the Mg-ferrite was ca. 86 J・min^<-1>・g^<-1> under AC magnetic field (200 W, 370 kHz). The heating ability in alternating magnetic field was clearly depended on the magnitude of the hysteresis loss for the ferrite powder. Fine Mg_<1-x>Ca_xFe_2O_4 ferrite powders for local thermal coagulation therapy were synthesized by a reverse coprecipitation method. The enhancement of temperature under an AC magnetic field was improved by the partial Ca^<2+> substitution. A high heat ability was obtained for the samples calcined at 300℃ and 800℃.

选择铁氧体粉末和合适的频率，实现肿瘤填充铁氧体粉末后，通过外部线圈施加交变磁场局部加热至60-80℃的热凝固技术。在80 kHz ~ 399 kHz的交变磁场中对各种铁氧体粉末进行了加热。在此频率范围内，MgFe_2O_4的温升（ΔT）最大。ΔT值几乎与施加的功率和粉末的重量成正比。镁铁氧体的发热能力约为1000 ℃。86 J·min^<-1>·g^<-1>。铁氧体粉末在交变磁场中的加热能力明显取决于磁滞损耗的大小。采用<1-x>反向共沉淀法制备了用于局部热凝治疗的Mg_ Ca_xFe_2O_4铁氧体微粉。部分Ca^&lt;2+&gt;取代改善了交流磁场下的温度提高。在300℃和800℃煅烧的样品具有较高的耐热性。

项目成果

癌の加温治療を目的とした磁性材料の開発

开发用于癌症加热治疗的磁性材料

• 发表时间: 2004
• 期刊: 工学ジャーナル 第3巻
• 作者: 青野宏通;平澤英之;矢野 潤;猶原 隆;前原常弘;小西健介;渡部祐司
• 通讯作者: 渡部祐司

Development of Ferrite Materials for Local Cauterization of Cancer

用于癌症局部烧灼的铁氧体材料的开发

• 发表时间: 2004
• 期刊: Annual Journal of Engineering Ehime Uni. Vol.3
• 作者: H.Aono;H.Hirazawa;J.Yano;T.Naohara;T.Maehara;K.Koishi;Y.Watanabe
• 通讯作者: Y.Watanabe

交流磁場中で発熱する粉末材料およびその製造方法

在交变磁场中发热的粉末材料及其制造方法

• 发表时间: 2004

Konishi, Maehara, Kamimori, Aono, et al.: "Heating Ferrite Powder with AC Magnetic Field for Thermal Coagulation Therapy"J.Magn.Magn.Mater.. (印刷中).

Konishi、Maehara、Kamimori、Aono 等人：“用交流磁场加热铁氧体粉末进行热凝治疗”J.Magn.Magn.Mater..（正在印刷中）。

Selection of ferrite powder for thermal coagulation therapy with alternating magnetic field

• DOI: 10.1007/s10853-005-5698-x
• 发表时间: 2005
• 期刊: Journal of Materials Science
• 影响因子: 4.5
• 作者: T. Maehara;Kensuke Konishi;T. Kamimori;H. Aono;H. Hirazawa;T. Naohara;S. Nomura;H. Kikkawa;Y. Watanabe;Kanji Kawachi