An Etiologic and therapeutic study on canine necrotizing meningoencephalitis

对犬坏死性脑膜脑炎（NME）进行了遗传学、病原学和治疗学研究。对4个家系的哈巴狗脑脊液中胶质细胞酸性蛋白进行了遗传学研究。因此，NME被认为是一种常染色体隐性遗传疾病。通过病因学研究，在NME脑脊液中发现GFAP-抗体复合物和抗转氨酶自身抗体。在治疗研究中，对患有NME的狗检查了三种免疫抑制方案。不同治疗方案的生存时间和神经功能评分无显著差异。

Genetic, etiologic and therapeutic studies were performed on canine mecrotizing meningoencephalitis (NME). The genetic study consisted of the determination of glial fibrillary acidic protein in the cerebrospinal fluids from Pug dogs in 4 families. As a result, NME was suggested to be an autosomal recessive disorder. By the etiologic studies, GFAP-antibody complexes and anti-transglutaminase autoantibodies were demonstrated in the NME cerebrospinal fluids. In the therapeutic study, three immunosuppressive protocols were examined on dogs with NME. No significant difference was observed in the survival times and neurological scores among the therapeutic protocols.