Effect of tactile stimulation applied during infantile period on various autonomic functions in rats.

婴儿期触觉刺激对大鼠各种自主神经功能的影响。

• 批准号: 15590214
• 负责人: KUROSAWA Mieko
• 金额: $ 2.11万
• 依托单位: International University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590214/
• 关键词: touch; autonomic function; stress; growth; blood pressure; heart rate; reflex responses; infantile period; 側坐核; ドーパミン; 報酬系; 脊髄血流; 分節性反応; 全身性反応; ラット; 脊髄反射; 交感神経; 迷走神経; 成長; 摂食量; 皮膚

The objective of this study was to investigate the effect of repeated tactile stimulation applied during infantile period on various autonomic functions. The experiments were performed in rats. The tactile stimulation was applied by stroking manually the abdominal skin area for 5 min every day during 4 weeks after 25 days of age. Following results were obtained.1.Repeated massage-like stroking prevented stress-induced retardation of growth. The effects were not observed under food restriction, suggesting that the effects of tactile stimulation on body weight were mediated via modulation of food intake.2.Repeated massage-like stroking augmented spinal autonomic responses of blood pressure and heart rate to noxious pinching; however, the treatment showed no changes in these responses in the rats with intact central nervous system, suggesting that the repeated massage-like stroking might augment descending inhibitory pathways on spinal reflex arcs.3.Repeated massage-like stroking had no influence on the responses of dopamine release from the nucleus accumbens, which is known to influence autonomic functions, to innocuous brushing and noxious pinching.These results indicate that tactile stimulation applied during infantile period can affect various autonomic functions.

本研究的目的是探讨婴儿期重复触觉刺激对各种自主神经功能的影响。实验是在大鼠身上进行的。 25日龄后4周内，每天用手抚摸腹部皮肤区域5分钟来施加触觉刺激。获得以下结果： 1.反复按摩式抚摸可防止应激引起的生长迟缓。在食物限制下没有观察到这种影响，这表明触觉刺激对体重的影响是通过调节食物摄入量来介导的。2.重复按摩式抚摸增强了脊柱对有害捏捏的血压和心率自主反应；然而，在中枢神经系统完整的大鼠中，治疗显示这些反应没有变化，这表明重复的按摩式抚摸可能会增强脊髓反射弧的下行抑制通路。3.重复的按摩式抚摸对伏隔核释放的多巴胺没有影响，伏隔核释放的多巴胺会影响自主神经功能，对无害的刷牙和有害的捏捏的反应没有影响。这些结果表明 婴儿期施加的触觉刺激会影响各种自主神经功能。

项目成果

コメディカルのための専門基礎分野テキスト生理学

喜剧医学专业基础领域教材生理学

• 发表时间: 2006
• 作者: Sato N;Kanai S;Takano S;Kurosawa M;Funakoshi A;Miyasaka K;Stener-Victorirn E;黒澤美枝子
• 通讯作者: 黒澤美枝子

Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats

拉呋替丁通过增强大鼠中枢促甲状腺素释放激素的作用来增加肝血流量

• 发表时间: 2003
• 期刊: Journal of Gastroenterology and Hepatology 18
• 作者: 下重里江;黒澤美枝子;Shimoju-Kobayashi R;Stener-Victorin E;Kurosawa M;Hashimoto T;Stener-Victorin E;Yoneda M
• 通讯作者: Yoneda M

Intraportal nicotine infusion in rats decreases hepatic blood flow dthrough endothelin-1 and both endothelin A and endothelin B receptors.

大鼠门静脉输注尼古丁可减少通过内皮素-1、内皮素 A 和内皮素 B 受体的肝血流量。

• 发表时间: 2004
• 期刊: Toxicology and Applied Pharmacology 196・1
• 作者: 下重里江;黒澤美枝子;Shimoju-Kobayashi R;Stener-Victorin E;Kurosawa M;Hashimoto T
• 通讯作者: Hashimoto T

Yoneda M: "Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats"Journal of Gastroenterology and Hepatology. 18. 177-184 (2003)

米田 M：“拉呋替丁通过增强大鼠中枢促甲状腺素释放激素的作用来增加肝脏血流量”胃肠病学和肝脏病学杂志。

Ovarian blood flow responses to electro-acupuncture stimulation at different frequencies and intensities in anaesthetized rats

• DOI: 10.1016/j.autneu.2003.08.006
• 发表时间: 2003-10-31
• 期刊: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
• 影响因子: 2.7
• 作者: Stener-Victorin, E;Kobayashi, R;Kurosawa, M
• 通讯作者: Kurosawa, M