Is the disturbed early phase insulin response prescribed by the genetical role?

早期胰岛素反应紊乱是否是由遗传作用决定的？

• 批准号: 15590491
• 负责人: MIZUNO Akira
• 金额: $ 2.3万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590491/
• 关键词: Portal glucose sensor; Clamp-CPR-OGL method; Early phase insulin response; Obese subject; Impaired glucose tolerance

lesion but not in pancreas and cephalic lesion. Previous study would suggest that hindrance in early phase insulin response (EPIS) is strongly related to onset and worsen type 2 diabetes mellitus. Measurement of EPIS using Clamp-OGL-CPR method was underwent in over 70 patients with obese and impaired glucose tolerance, although it had been done in only 30 subjects without obesity and normal glucose tolerance. We analyzed the EIS during Clamp-OGL-CPR method in normal subject who were divided into two groups, one group with diabetic diathesis and the other group without that, after the measurement of insulinogenic index during 75g OGTT. The results suggested that responsiveness of EPIS correlated with insulinogenic index and the diathesis of type 2 DM did not relate to disturbance in EPIS. After these studies, we started genetic markers concerning hindrances in EPIS, which reported to be existing in intestine and portal vein. We evaluated the polymorphism of glucokinase (GK) gene, although no significant difference was not determined between the two groups. Now we have been searching the diadetic gene, which will be related to portal glucose sensor.

病变，但不在胰腺和头膜病变中。先前的研究表明，早期胰岛素反应（EPIS）的障碍与发作密切相关，并恶化2型糖尿病。在70多名肥胖且葡萄糖耐受性受损的患者中，使用夹具-OGL-CPR方法对EMIP进行了测量，尽管仅在30名没有肥胖症和正常葡萄糖耐受性的受试者中进行。我们在正常受试者中分析了分为两组的正常受试者中的EIS，一组糖尿病性糖尿病，另一组没有此组，在测量75G OGTT期间的胰岛素生成指数之后。结果表明，EPIP的响应能力与胰岛素生成指数相关，而2型DM的透视与EPIS中的干扰无关。经过这些研究，我们启动了有关EPIS中障碍的遗传标记，据报道存在于肠道和门静脉中。我们评估了葡萄糖酶（GK）基因的多态性，尽管两组之间未确定没有显着差异。现在，我们一直在搜索与门户葡萄糖传感器有关的Diadetic基因。

项目成果

Effect of novel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male splaque-dawley rats after short- and long-term ingestion.

新型帕拉金糖液体平衡配方（MHN-01）短期和长期摄入后对雄性 splaque-dawley 大鼠葡萄糖和脂质代谢的影响。

• 发表时间: 2004
• 期刊: Metabolism 53(8)
• 作者: 水野 明;Akira Mizuno;水野 昭;Hidekazu Arai;Hidekazu Arai
• 通讯作者: Hidekazu Arai

Arai E: "Effect of a novel palatinose-based liquid formula(MHN-01)on glucose and lipid metabolism in male Sprague-Dawley rats after short- and long- term ingestion"Metabolism. (In press).

Arai E：“新型帕拉金糖液体配方（MHN-01）对雄性斯普拉格-道利大鼠短期和长期摄入后葡萄糖和脂质代谢的影响”代谢。

Mizuno A: "Disturved early phase insulin secretion in prediabetic subjects"Diabetes(supple). (In press).

Mizuno A：“糖尿病前期受试者早期胰岛素分泌紊乱”糖尿病（补充）。

耐糖能異常および肥満の改善効果が期待できる新規流動食(MHN-01)の開発

开发新型流质饮食（MHN-01），有望改善葡萄糖不耐受和肥胖

• 发表时间: 2003
• 期刊: 栄養評価と治療 20・6
• 作者: 水野 明;Akira Mizuno;水野 昭;Hidekazu Arai;Hidekazu Arai;Arai H;庄司 有里;新井 英一
• 通讯作者: 新井 英一

Development of novel liquid balanced formula (MHN-01) possessing the ability to ameliorate glucose tolerance of obese subjects.

开发具有改善肥胖受试者葡萄糖耐量能力的新型液体平衡配方（MHN-01）。

• 发表时间: 2003
• 期刊: Lapanese Journal of Nutritional Assessment 20(6)
• 作者: 水野 明;Akira Mizuno;水野 昭;Hidekazu Arai;Hidekazu Arai;Arai H;庄司 有里;新井 英一;Yuri Shoiji;Hidekazu Arai
• 通讯作者: Hidekazu Arai