Is the disturbed early phase insulin response prescribed by the genetical role?

病变，但不在胰腺和头部病变。先前的研究表明，早期阶段胰岛素反应障碍(EPIS)与2型糖尿病的发病和恶化密切相关。应用CLAMP-OGL-CPR方法对70多例肥胖和糖耐量减低患者进行了EPIS检测，但仅对30例非肥胖者和正常糖耐量受试者进行了EPIS检测。测定75g OGTT时的胰岛素分泌指数，将正常受试者分为糖尿病素质组和非糖尿病素质组，对钳夹-OGL-CPR法中的EIS进行分析。结果提示，EPIS的反应性与胰岛素分泌指数相关，而2型糖尿病患者的素质与EPIS的障碍无关。在这些研究之后，我们开始了与EPIS障碍相关的遗传标记，据报道，这些障碍存在于肠道和门静脉。我们评估了葡萄糖激酶(GK)基因的多态性，尽管两组之间没有显著差异。目前，我们一直在寻找与门静脉血糖感受器相关的黄递素基因。

lesion but not in pancreas and cephalic lesion. Previous study would suggest that hindrance in early phase insulin response (EPIS) is strongly related to onset and worsen type 2 diabetes mellitus. Measurement of EPIS using Clamp-OGL-CPR method was underwent in over 70 patients with obese and impaired glucose tolerance, although it had been done in only 30 subjects without obesity and normal glucose tolerance. We analyzed the EIS during Clamp-OGL-CPR method in normal subject who were divided into two groups, one group with diabetic diathesis and the other group without that, after the measurement of insulinogenic index during 75g OGTT. The results suggested that responsiveness of EPIS correlated with insulinogenic index and the diathesis of type 2 DM did not relate to disturbance in EPIS. After these studies, we started genetic markers concerning hindrances in EPIS, which reported to be existing in intestine and portal vein. We evaluated the polymorphism of glucokinase (GK) gene, although no significant difference was not determined between the two groups. Now we have been searching the diadetic gene, which will be related to portal glucose sensor.