Risk evaluation of the reproductive effects of chemicals acting on the nervous system in the occupationally exposed population

我们评估了暴露于作用于神经系统的农药的工人的生殖功能。对某农药公司54名男性职工进行了问卷调查，询问职工的主观症状和子女性别比。其中34名工人测定了血清睾酮、促卵泡激素（FSH）和促黄体生成素（LH）浓度，接触浓度的时间-重量平均值，以及杀虫剂和溶剂代谢产物的尿浓度。按WHO手册对6名作业工人进行精液检查。尿溴离子浓度，有机卤代农药的代谢产物，显着高于在对照组的工人接触。除甲苯（2.5-13.5 ppm）和乙酸乙酯（1.5-7.3 ppm）外，溶剂浓度几乎与一般人群相当，这表明它们低于职业接触限值。无意义 关于我们 工蜂子代的性别比和子代的性别比存在显著差异。工人年龄与FSH浓度呈显著正相关。精液指标均在正常范围内，但参与率仅为11.5%。总体而言，不太可能对工人的生殖产生任何显着的毒性影响。另一项关于农药喷雾器的精液研究显示，在夏季农药喷洒工作最多时，与未接触对照组相比，活力较低的精子显着增加。然而，其他指数没有积极的生物学相关结果。因此，我们给雄性大鼠施用敌敌畏，暗示睾丸毒物，持续9周。结果表明，在诱导乙酰胆碱酯酶显著抑制的剂量下，活动精子的百分比显著但小幅增加。我们无法得出结论，认为工人中观察到的影响仅归因于敌敌畏暴露。少

We evaluated the reproductive function of workers exposed to pesticides acting on the nervous system. A questionnaire survey was conducted on 54 males of a pesticide company, asking the workers their subjective symptoms and the sex ratio of their offspring. Of them, the following indices were measured for 34 workers ; the serum concentrations of testosterone, follicle stimulating hormone(FSH) and luteinizing hormone, the time-weight average of exposure concentrations, and the urinary concentrations of metabolites of the insecticide and solvents. Semen indices of six workers were examined according to the WHO manual. Urinary bromide ion concentrations, a metabolite of an organohalogenated pesticide, were significantly higher in the exposed workers than in the controls. The solvent concentrations were almost comparable with the general population except for toluene (2.5-13.5 ppm) and ethyl acetate (1.5-7.3 ppm), indicating that they were below the occupational exposure limits. No signifi … More cant differences were observed as to that of the workers' offspring and their sex ratio. A significant positive correlation was observed between the age of the workers and the FSH concentration. Semen indices were within normal limits, but the participation ratio was only 11.5%. As a whole, it is unlikely that there is any significant toxic effect on the reproduction of the workers.Another semen study on pesticide sprayers revealed a significant increase in sperm with lower motility compared to the non-exposed controls in summer when pesticide-spraying work is at maximum. However, there was no positive biologically relevant finding for other indices. Thus, we administered dichlorvos, suggestive of a testicular toxicant, to male rats for 9 weeks. The results showed a significant but small increase in the percentage of motile sperm at doses inducing marked inhibition of acetylcholine esterase. We could not conclude that the observed effects in the workers were attributable to dichlorvos exposure alone. Less