Risk evaluation of the reproductive effects of chemicals acting on the nervous system in the occupationally exposed population

化学品对职业暴露人群神经系统生殖影响的风险评估

• 批准号: 15590510
• 负责人: KAMIJIMA Michihiro
• 金额: $ 2.37万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590510/
• 关键词: chemicals; reproductive effect; risk assessment; semen; occupational exposure; workplace; 生殖機能; 曝露; 尿中代謝物; 精液指標; 性ホルモン; 性比

We evaluated the reproductive function of workers exposed to pesticides acting on the nervous system. A questionnaire survey was conducted on 54 males of a pesticide company, asking the workers their subjective symptoms and the sex ratio of their offspring. Of them, the following indices were measured for 34 workers ; the serum concentrations of testosterone, follicle stimulating hormone(FSH) and luteinizing hormone, the time-weight average of exposure concentrations, and the urinary concentrations of metabolites of the insecticide and solvents. Semen indices of six workers were examined according to the WHO manual. Urinary bromide ion concentrations, a metabolite of an organohalogenated pesticide, were significantly higher in the exposed workers than in the controls. The solvent concentrations were almost comparable with the general population except for toluene (2.5-13.5 ppm) and ethyl acetate (1.5-7.3 ppm), indicating that they were below the occupational exposure limits. No signifi … More cant differences were observed as to that of the workers' offspring and their sex ratio. A significant positive correlation was observed between the age of the workers and the FSH concentration. Semen indices were within normal limits, but the participation ratio was only 11.5%. As a whole, it is unlikely that there is any significant toxic effect on the reproduction of the workers.Another semen study on pesticide sprayers revealed a significant increase in sperm with lower motility compared to the non-exposed controls in summer when pesticide-spraying work is at maximum. However, there was no positive biologically relevant finding for other indices. Thus, we administered dichlorvos, suggestive of a testicular toxicant, to male rats for 9 weeks. The results showed a significant but small increase in the percentage of motile sperm at doses inducing marked inhibition of acetylcholine esterase. We could not conclude that the observed effects in the workers were attributable to dichlorvos exposure alone. Less

我们评估了接触过作用于神经系统的农药的工人的生殖功能。对某农药公司54名男性工人进行问卷调查，询问其主观症状及子女性别比。其中，对34名工人测量了以下指标：睾酮、卵泡刺激素（FSH）和黄体生成素的血清浓度，暴露浓度的时间-重量平均值，以及杀虫剂和溶剂代谢物的尿浓度。根据世界卫生组织手册对六名工人的精液指数进行了检查。暴露工人的尿溴离子浓度（一种有机卤化农药的代谢物）显着高于对照组。除甲苯（2.5-13.5 ppm）和乙酸乙酯（1.5-7.3 ppm）外，溶剂浓度几乎与一般人群相当，表明它们低于职业接触限值。工人们的后代及其性别比例没有观察到显着差异。工人年龄与FSH浓度呈显着正相关。精液指数在正常范围内，但参与率仅为11.5%。总体而言，不太可能对工人的生殖产生任何显着的毒性影响。另一项针对农药喷洒器的精液研究显示，与未暴露的对照相比，在夏季喷洒农药工作量最大的情况下，与未暴露的对照相比，精子的活力显着增加。然而，其他指标没有积极的生物学相关发现。因此，我们对雄性大鼠施用敌敌畏（暗示存在睾丸毒物）9周。结果显示，在显着抑制乙酰胆碱酯酶的剂量下，活动精子的百分比显着但小幅增加。我们无法得出结论认为，在工人中观察到的影响仅归因于敌敌畏暴露。较少的

项目成果

Neurological abnormalities in workers of 1-bromopropane factory.

1-溴丙烷工厂工人的神经系统异常。

• 发表时间: 2004
• 期刊: Environ Health Persp 112
• 作者: Ichihara G;et al.
• 通讯作者: et al.

上島通浩, 柴田英治: "臨床医のための「有機溶剤中毒」 2.有機溶剤職場の産業医に必要な視点"日本医事新報. 4144. 33-36 (2003)

Michihiro Ueshima、Eiji Shibata：“临床医生的‘有机溶剂中毒’2。在有机溶剂工作场所工作的工业医生的必要观点”Nippon Iji Shinpo 4144. 33-36 (2003)。

Kamijima M et al.: "A Survey of Semen Indices in Insecticide Sprayers"Journal of Occupational Health. 46(In Press). (2004)

Kamijima M 等人：“杀虫剂喷雾器精液指数调查”职业健康杂志。

A survey of semen indices in insecticide sprayers

• DOI: 10.1539/joh.46.109
• 发表时间: 2004-03-01
• 期刊: JOURNAL OF OCCUPATIONAL HEALTH
• 影响因子: 3
• 作者: Kamijima, M;Hibi, H;Takeuchi, Y
• 通讯作者: Takeuchi, Y

Health effects of exposure to ethylene glycol monoethyl ether in female workers

女工接触乙二醇单乙醚对健康的影响

• 发表时间: 2004
• 期刊: Ind Health 42
• 作者: Kamijima M;Ichihara G;Wang RS
• 通讯作者: Wang RS