MRF based B1+ mapping for 7T Magnetic Resonance Electrical Properties Tomography and RF pulse design
基于 MRF 的 B1 映射,用于 7T 磁共振电特性断层扫描和射频脉冲设计
基本信息
- 批准号:464387898
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
While the first clinical magnetic resonance imaging (MRI) scanners introduced in the early 1980s still operated at a magnetic field strength of 0.2-0.5 Tesla (T), today's clinical MRI scanners typically operate at a field strength of 1.5 and 3 T. In addition, so-called ultra high field (UHF) MRI devices operating at 7 T and more are increasingly being investigated for clinical use and scientific purposes. The advantage of the high field strengths is especially the higher signal-to-noise ratio (SNR), which allows a higher spatial and temporal resolution of the images and which can accelerate the image acquisition process. However, a major challenge of UHF MRI is the spatially inhomogeneous contrast and the inhomogeneous signal of the image. These are caused by the spatially inhomogeneous distribution of the radio frequency (RF) fields, especially their magnetic component (B1+), which is responsible for the excitation of the nuclear spins. Although this inhomogeneous distribution can be compensated by using several transmitters (the "RF coils") and special RF pulses, this approach requires a very precise mapping of the spatial three-dimensional B1+ fields of the individual transmitters. Besides the possibility to compensate this inhomogeneity, B1+ mapping also offers high potential to obtain information about the electrical properties of the human tissue, i.e. conductivity (as a measure of the possibility of conducting electric currents) and permittivity (as a measure of the electric polarizability). These are of interest because they vary greatly as a function of tissue type and cell composition, and thus tumor tissue can possibly be detected and differentiated. Despite its potential, however, 'electrical properties tomography' (EPT) has not been widely used so far. Among the reasons for this fact is the demand for high SNR in the B1+ field maps, and also the lack of large patient studies with sufficient statistical significance.The aim of this proposal is to develop an accurate and precise method for mapping the B1+ fields in the human head and the body that will benefit from the high SNR available at 7 T. For this purpose, the principle of "Magnetic Resonance Fingerprinting" (MRF) will be used, which is becoming increasingly important in quantitative MRI as it promises high encoding efficiency. The obtained maps will be compared to an existing but biased method and the impact of the novel technique i) on the derived electric properties values and ii) on the achieved spatial homogeneity in UHF body imaging will be analyzed. In the long term, the developed technique enables the investigation of novel methods for UHF body imaging and serves for future EPT studies with tumor patients.
虽然在20世纪80年代早期引入的第一台临床磁共振成像(MRI)扫描仪仍在0.2-0.5特斯拉(T)的磁场强度下工作,但今天的临床MRI扫描仪通常在1.5和3 T的磁场强度下工作。此外,在7 T和更高温度下工作的所谓超高场(UHF)MRI设备越来越多地被研究用于临床使用和科学目的。高场强的优势尤其是更高的信噪比(SNR),这使得图像具有更高的空间和时间分辨率,并且可以加速图像采集过程。然而,UHF MRI的主要挑战是图像的空间非均匀对比度和非均匀信号。这是由射频场的空间不均匀分布引起的,特别是它们的磁分量(B1+),它负责激发核自旋。虽然这种不均匀分布可以通过使用几个发射器(“RF线圈”)和特殊的RF脉冲来补偿,但这种方法需要非常精确地映射各个发射器的空间三维B1+场。除了补偿这种不均匀性的可能性之外,B1+标测还提供了获得关于人体组织的电特性的信息的高潜力,即电导率(作为传导电流的可能性的量度)和介电常数(作为电极化率的量度)。这些是令人感兴趣的,因为它们作为组织类型和细胞组成的函数变化很大,因此可能检测和区分肿瘤组织。尽管它的潜力,但是,“电特性层析成像”(EPT)尚未被广泛使用。造成这一事实的原因之一是B1+场图中对高SNR的需求,以及缺乏具有足够统计学意义的大型患者研究。本提案的目的是开发一种准确和精确的方法,用于绘制人体头部和身体中的B1+场,这将受益于7 T下的高SNR。为此,将使用“磁共振指纹”(MRF)的原理,这在定量MRI中变得越来越重要,因为它承诺高编码效率。将所获得的地图与现有但有偏差的方法进行比较,并分析新技术i)对导出的电特性值和ii)对UHF身体成像中实现的空间均匀性的影响。从长远来看,所开发的技术能够研究UHF身体成像的新方法,并为未来肿瘤患者的EPT研究服务。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dr. Sebastian Schmitter其他文献
Dr. Sebastian Schmitter的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Dr. Sebastian Schmitter', 18)}}的其他基金
Investigating respiratory motion induced changes on EM fields and SAR in UHF body MRI
研究 UHF 身体 MRI 中呼吸运动引起的电磁场和 SAR 变化
- 批准号:
405363511 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Research Grants
Softwaretechnische Entwicklung von elektromagnetischen Hochfrequenzpulsen (HF-Pulse) für die Ultrahochfeld-Magneresonanztomographie (UHF-MRT) unter Verwendung von Mehrkanal-Hochfrequenz-Sendeeinheiten
使用多通道高频发射机单元进行超高场磁共振成像 (UHF-MRI) 电磁高频脉冲(HF 脉冲)的软件开发
- 批准号:
149260024 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Research Fellowships
Development of a fully automatic, 20-second long deep-learning based calibration procedure for parallel transmission (pTx) in ultrahigh field MR body imaging
开发基于 20 秒长深度学习的全自动校准程序,用于超高场 MR 人体成像中的并行传输 (pTx)
- 批准号:
524729317 - 财政年份:
- 资助金额:
-- - 项目类别:
Research Grants
相似国自然基金
Data-driven Recommendation System Construction of an Online Medical Platform Based on the Fusion of Information
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国青年学者研究基金项目
Incentive and governance schenism study of corporate green washing behavior in China: Based on an integiated view of econfiguration of environmental authority and decoupling logic
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国学者研究基金项目
Exploring the Intrinsic Mechanisms of CEO Turnover and Market Reaction: An Explanation Based on Information Asymmetry
- 批准号:W2433169
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国学者研究基金项目
含Re、Ru先进镍基单晶高温合金中TCP相成核—生长机理的原位动态研究
- 批准号:52301178
- 批准年份:2023
- 资助金额:30.00 万元
- 项目类别:青年科学基金项目
NbZrTi基多主元合金中化学不均匀性对辐照行为的影响研究
- 批准号:12305290
- 批准年份:2023
- 资助金额:30.00 万元
- 项目类别:青年科学基金项目
眼表菌群影响糖尿病患者干眼发生的人群流行病学研究
- 批准号:82371110
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
镍基UNS N10003合金辐照位错环演化机制及其对力学性能的影响研究
- 批准号:12375280
- 批准年份:2023
- 资助金额:53.00 万元
- 项目类别:面上项目
CuAgSe基热电材料的结构特性与构效关系研究
- 批准号:22375214
- 批准年份:2023
- 资助金额:50.00 万元
- 项目类别:面上项目
A study on prototype flexible multifunctional graphene foam-based sensing grid (柔性多功能石墨烯泡沫传感网格原型研究)
- 批准号:
- 批准年份:2020
- 资助金额:20 万元
- 项目类别:
基于大数据定量研究城市化对中国季节性流感传播的影响及其机理
- 批准号:82003509
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Optimal utility-based design of oncology clinical development programmes
基于效用的肿瘤学临床开发项目的优化设计
- 批准号:
2734768 - 财政年份:2026
- 资助金额:
-- - 项目类别:
Studentship
Plasmonic Mg-based catalysts for low temperature sunlight-assisted CO2 activation (MgCatCO2Act)
用于低温阳光辅助 CO2 活化的等离子体镁基催化剂 (MgCatCO2Act)
- 批准号:
EP/Y037294/1 - 财政年份:2025
- 资助金额:
-- - 项目类别:
Research Grant
Impact of Urban Environmental Factors on Momentary Subjective Wellbeing (SWB) using Smartphone-Based Experience Sampling Methods
使用基于智能手机的体验采样方法研究城市环境因素对瞬时主观幸福感 (SWB) 的影响
- 批准号:
2750689 - 财政年份:2025
- 资助金额:
-- - 项目类别:
Studentship
Bio-MATSUPER: Development of high-performance supercapacitors based on bio-based carbon materials
Bio-MATSUPER:开发基于生物基碳材料的高性能超级电容器
- 批准号:
EP/Z001013/1 - 财政年份:2025
- 资助金额:
-- - 项目类别:
Fellowship
Flexible fMRI-Compatible Neural Probes with Organic Semiconductor based Multi-modal Sensors for Closed Loop Neuromodulation
灵活的 fMRI 兼容神经探针,带有基于有机半导体的多模态传感器,用于闭环神经调节
- 批准号:
2336525 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
CAREER: Rank Metric Codes from Drinfeld Modules and New Primitives in Code Based Cryptography
职业:对来自 Drinfeld 模块的度量代码和基于代码的密码学中的新原语进行排名
- 批准号:
2338424 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Continuing Grant
CAREER: Data-Enabled Neural Multi-Step Predictive Control (DeMuSPc): a Learning-Based Predictive and Adaptive Control Approach for Complex Nonlinear Systems
职业:数据支持的神经多步预测控制(DeMuSPc):一种用于复杂非线性系统的基于学习的预测和自适应控制方法
- 批准号:
2338749 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
RII Track-4:NSF: Design of zeolite-encapsulated metal phthalocyanines catalysts enabled by insights from synchrotron-based X-ray techniques
RII Track-4:NSF:通过基于同步加速器的 X 射线技术的见解实现沸石封装金属酞菁催化剂的设计
- 批准号:
2327267 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
EAGER: Generalizing Monin-Obukhov Similarity Theory (MOST)-based Surface Layer Parameterizations for Turbulence Resolving Earth System Models (ESMs)
EAGER:将基于 Monin-Obukhov 相似理论 (MOST) 的表面层参数化推广到湍流解析地球系统模型 (ESM)
- 批准号:
2414424 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
Conference: 2024 Thiol-Based Redox Regulation and Signaling GRC and GRS: Mechanisms and Consequences of Redox Signaling
会议:2024年基于硫醇的氧化还原调节和信号传导GRC和GRS:氧化还原信号传导的机制和后果
- 批准号:
2418618 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant