The role of intracellular calcium dynamism on the activation of intestinal mucosal immune cells

细胞内钙动态对肠粘膜免疫细胞激活的作用

• 批准号: 15590637
• 负责人: IKUMA Mutsuhiro
• 金额: $ 2.05万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590637/
• 关键词: inflammatory bowel disease; mucosal immunology; intracellular calcium

Intestinal epithelium award active barrier, which, as with its normal status, maintains regulated uptake of nutrients and fluids, and then are simultaneously excluding potential pathogens. Enteric diseases, including inflammatory bowel disease (IBD) cause disconcerted epithelial function. Although IBD seems to be born in idiopathic, it is obvious that the pathophysiology of the IBD is due to inopportune or exaggerated immunological reactions. Relatively few studies have demonstrated role of intracellular ion status and transmembrane ion movement on epithelial immune function. Several features, including technical matter, correspond to difficulties such studies. This booklet is devoted as report of the Japanese National Grant-in-Aid for Scientific Research (C) 'KAKENHI" #15590637 : "The study for intracellular calcium and ion dynamics in the regulation of intestinal immune cells" through 2003-2004 fiscal year. In the separately published synopsis I will illustrate the core of the study and review the current status of this area's advancement, along with our recent publications. What is conceivably most marked is the fact that we have only begun to recognize the role of anion transport mechanism and the contribution of the divalent cation (e.g., calcium) on that for the core cell function in the immune systems. The experience may lead to further advancement in this research fields.

肠上皮细胞授予主动屏障，其与其正常状态一样，维持营养物质和液体的调节摄取，然后同时排除潜在的病原体。包括炎症性肠病（IBD）在内的肠道疾病引起上皮功能紊乱。虽然IBD似乎是先天性的，但很明显，IBD的病理生理学是由于不合时宜或夸大的免疫反应。相对较少的研究表明细胞内离子状态和跨膜离子运动对上皮免疫功能的作用。包括技术问题在内的几个特点与这些研究的困难相对应。这本小册子是日本国家科学研究资助（C）“KAKENHI”#15590637：“肠道免疫细胞调节中的细胞内钙和离子动力学研究”的报告，截止2003-2004财政年度。在单独出版的概要中，我将说明研究的核心，并回顾这一领域的进展现状，沿着我们最近的出版物。可以想象的是，最显著的事实是，我们才开始认识到阴离子转运机制的作用和二价阳离子的贡献（例如，钙）对免疫系统中核心细胞功能的影响。这些经验可能会导致该研究领域的进一步发展。

项目成果

Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon

• DOI: 10.1152/ajpcell.00396.2002
• 发表时间: 2003-10-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
• 影响因子: 5.5
• 作者: Ikuma, M;Geibel, J;Rajendran, VM
• 通讯作者: Rajendran, VM

Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain

• DOI: 10.1073/pnas.0408575102
• 发表时间: 2005-01-11
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Berger, AL;Ikuma, M;Welsh, MJ
• 通讯作者: Welsh, MJ

Characterization of CI-HCO_3 exchange in basolateral membrane of rat distal colon.

大鼠远端结肠基底外侧膜 CI-HCO_3 交换的表征。

• 发表时间: 2003
• 期刊: American Journal of Cell Physiology 285(4)
• 作者: Allan Berger;Mutsuhiro IKUMA et al.;Mutsuhiro IKUMA;Mutsuhiro IKUMA et al.;Mutsuhiro IKUMA
• 通讯作者: Mutsuhiro IKUMA

Mutsuhiro IKUMA: "Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon"Am J Physiol Cell Physiol.. 285(4). C912-C921 (2003)

Mutsuhiro IKUMA：“大鼠远端结肠基底外侧膜中 Cl-HCO3 交换的表征”Am J Physiol Cell Physiol.. 285(4)。