Crosstalk and the regulation of intestinal immune cells: mucosal dendritic cells and intraepithelial lymphocytes

肠道免疫细胞的串扰和调节：粘膜树突状细胞和上皮内淋巴细胞

• 批准号: 17590629
• 负责人: IKUMA Mutsuhiro
• 金额: $ 2.3万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590629/
• 关键词: mucosal immunity; intraepithelial lymphocyte; cytokine; mucosal nutrition; 消化管免疫; 細胞内イオン; 樹状細胞; 上皮間リンパ球

Intestinal epithelium grant active barrier, which, as with its natural status, maintains regulated uptake of nutrients and fluids, and then are simultaneously excluding potential pathogens. Enteral diseases, including inflammatory bowel disease (IBD) cause disconcerted epithelial function. Although IBD seems to be born in idiopathic and multi-step causatives, it is clear that the pathophysiology of the IBD is due to discomfited or exaggerated immunological reactions. Few studies have demonstrated the role of nutrients on mucosal immune function. This booklet is devoted as report of the Japanese National Grant-in-Aid for Scientific Research(C) "KAKENHI" #17590629: "Crosstalk and the regulation of intestinal immune cells : mucosal dendritic cells and intraepithelial lymphocytes" through 2005-2006 fiscal year. In this brief synopsis I will illustrate the core of the study and review the current status of this area's advancement, along with our recent publications. What is conceivably most marked is the fact that we have only begun to recognize the role of nutritional immune regulation and histaminergic immune regulatory mechanisms in the intestine. The experience may lead to further advancement in this research fields.

肠上皮赋予活性屏障，其与自然状态一样，维持营养和液体的调节摄取，同时排除潜在的病原体。肠道疾病，包括炎症性肠病（IBD）引起上皮功能紊乱。虽然IBD似乎是由特发性和多步骤的病因引起的，但很明显，IBD的病理生理是由于免疫反应失调或夸大。很少有研究证实营养物质对粘膜免疫功能的作用。这本小册子是日本国家科学研究补助金(C)“KAKENHI”#17590629：“肠免疫细胞的串音和调节：粘膜树突状细胞和上皮内淋巴细胞”在2005-2006财政年度的报告。在这篇简短的摘要中，我将说明研究的核心，并回顾这一领域的进展现状，以及我们最近的出版物。可以想象，最显著的事实是，我们才刚刚开始认识到营养免疫调节和组胺免疫调节机制在肠道中的作用。这一经验可能会导致这一研究领域的进一步发展。

项目成果

Alteration of intracellular histamine H_2 receptor cycling precedes antagonist-induced up-regulation

细胞内组胺 H_2 受体循环的改变先于拮抗剂诱导的上调

• 发表时间: 2005
• 期刊: Am J Physiol, Gastrointest Liver Physiol 289
• 作者: Osawa S;Kajimura M;Yamamoto S;Ikuma M;Mochizuki C;Iwasaki H;Hishida A;Terakawa S.
• 通讯作者: Terakawa S.

Outcome of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma refractory to helicobacter pylori eradication therapy

• DOI: 10.2169/internalmedicine.45.1473
• 发表时间: 2006-01-01
• 期刊: INTERNAL MEDICINE
• 影响因子: 1.2
• 作者: Sugimoto, Mitsushige;Kajimura, Masayoshi;Hishida, Akira
• 通讯作者: Hishida, Akira

Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain

• DOI: 10.1073/pnas.0408575102
• 发表时间: 2005-01-11
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Berger, AL;Ikuma, M;Welsh, MJ
• 通讯作者: Welsh, MJ

Initial 48‐hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype status

• DOI: 10.1016/j.clpt.2006.08.010
• 发表时间: 2006-11
• 期刊: Clinical Pharmacology & Therapeutics
• 影响因子: 6.7
• 作者: M. Sugimoto;T. Furuta;N. Shirai;M. Ikuma;A. Hishida;T. Ishizaki

Alteration of intracellular histamine H, receptor cycling precedes antagonist-induced up-regulation.

细胞内组胺 H 受体循环的改变先于拮抗剂诱导的上调。

• 发表时间: 2005
• 期刊: Am J Physiol Gastrointest Liver Physiol. 289(5)
• 作者: Osawa S;Kajimura M;Yamamoto S;Ikuma M;Mochizuki C;Iwasaki H;Hishida A. Terakawa S.
• 通讯作者: Hishida A. Terakawa S.