Clinical characteristics of hepatitis B virus genotypes
乙型肝炎病毒基因型的临床特征
基本信息
- 批准号:15590671
- 负责人:
- 金额:$ 2.24万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Hepatitis B virus (HBV) isolated in1965 by Dr. Blumberg et al. In 1988, HBV was firstly classified into four genotypes, A-D, by a nucleotide sequence difference greater 8 % in the entire genome, and designated by A to D. At present, there are seven genotypes of HBV by molecular evolutionary analysis and an eight, genotype H, is now on the horizon.HBV genotype A localize mainly in Europe, North Africa, and North and South America. HBV genotype B and C are very common in Asia. HBV genotype D is also mainly in the Mediterranean, the Middle and, Near East and South American countries. HBV genotype E is prevalent in West Africa. HBV genotype F and H localize in Central, and South America. HBV genotype G is still unknown, because of recently identified in 2000.The mutation for a stop codon in the precore region(G1896A)for stopping the translation of HBeAg is prohibited in HBV genomes of genotype A, as well as genotype C and F, because they have C at position 1858 that makes a Watson-Crick pair with G at position 1896. So, seroconversion to antibody to HBeAg is forbidden or delayed in individuals who infected the genotypes. Evidence is accumulating as regards the influence of HBV genotypes on the progression of chronic hepatitis B and response to antiviral therapies. These data strongly indicate that HBV genotypes play a big role of the difference of the response to antiviral therapy and that of clinical characteristics in each different HBV genotype infected carriers.10.
1965年Blumberg等人分离出乙型肝炎病毒(HBV)。1988年,乙型肝炎病毒首次根据全基因组核苷酸序列差异大于8%划分为a - d四种基因型,并以a到d命名。目前,通过分子进化分析,乙型肝炎病毒已划分为7种基因型,8种基因型H即将出现。HBV基因型A主要在欧洲、北非、北美和南美进行本地化。HBV基因型B和C在亚洲非常常见。HBV基因型D也主要分布在地中海、中东、近东和南美国家。乙型肝炎病毒基因型在西非流行。乙型肝炎病毒基因型F和H集中在中美洲和南美洲。HBV基因型G仍然未知,因为最近在2000年被发现。阻止HBeAg翻译的前区终止密码子(G1896A)突变在基因型a以及基因型C和F的HBV基因组中是被禁止的,因为它们在1858位有C,与1896位的G形成沃森-克里克对。因此,在感染基因型的个体中,血清转化为HBeAg抗体是被禁止或延迟的。关于HBV基因型对慢性乙型肝炎进展和抗病毒治疗反应的影响的证据越来越多。这些数据有力地表明,HBV基因型在不同HBV基因型感染携带者对抗病毒治疗的反应差异和临床特征差异中起着重要作用。
项目成果
期刊论文数量(79)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A longitudinal follow-up study on the hepatitis activity and viral replication before d after HBeAg seroconversion in chronic hepatitis B patients with genotypes B and C.
B、C基因型慢性乙型肝炎患者HBeAg血清转换后d前肝炎活动及病毒复制的纵向随访研究。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Sugauchi F. et al.;Sugauchi F. et al.;Kato H.et al.;Sakurai M. et al.;Hasegawa I. et al.;Tanaka Y. et al.;Ito K.et al.;Sugauchi F. et al.;Sugauchi F. et al.;Kato H.et al.;Sakurai M. et al.;Tanaka Y. et al.;Ito K.et al.;Duong TN. et al.;Sugauchi F. et al.;Yuen MF. et al.;Sugauchi F. et al.;Kato H.et al.;Hasegawa I. et al.;Sakurai M. et al.;Yuen MF. et al.
- 通讯作者:Yuen MF. et al.
Yuen MF.et al.: "Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations."Journal of Hepatology. 39・5. 850-855 (2003)
Yuen MF.等人:“YMDD 突变引起的乙型肝炎严重恶化的临床结果和病毒学特征”。《肝脏病学杂志》39・5(2003)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
Predicting relapse after cessation of Lamivudine monotherapy for chronic hepatitis B virus infection
预测慢性乙型肝炎病毒感染拉米夫定单药治疗停止后的复发
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Sugauchi F. et al.;Sugauchi F. et al.;Kato H.et al.;Sakurai M. et al.;Hasegawa I. et al.;Tanaka Y. et al.;Ito K.et al.
- 通讯作者:Ito K.et al.
Sugauchi F.et al.: "Genotype.serotype.and phylogenetic characterization of the complete genome sequence of hepatitis B virus isolates from Malawian chronic carriers of the virus"Journal of Medical Virology. 69・1. 33-40 (2003)
Sugauchi F.等人:“从马拉维慢性病毒携带者中分离出的乙型肝炎病毒的完整基因组序列的基因型、血清型和系统发育特征”《医学病毒学杂志》69·1(2003)。
- DOI:
- 发表时间:
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- 影响因子:0
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Sugauchi F.et al.: "Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver diseases."Journal of Medical Virology. 70. 537-544 (2003)
Sugauchi F.等人:“乙型肝炎病毒基因型对前S缺失和晚期肝脏疾病发展的影响。”医学病毒学杂志。
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- 影响因子:0
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MIZOKAMI Masashi其他文献
MIZOKAMI Masashi的其他文献
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{{ truncateString('MIZOKAMI Masashi', 18)}}的其他基金
Mechanism of drug resistance among HBV genotypes
HBV基因型耐药机制
- 批准号:
20390213 - 财政年份:2008
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
HBV genotype distribution in Japan and it's clinical significance
日本HBV基因型分布及其临床意义
- 批准号:
12670506 - 财政年份:2000
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Genotypic classification of GB virus C/Hepatitis G virus by molecular evolutionary analysis and its clinical application
丙型肝炎病毒/庚型肝炎病毒的分子进化分析基因型分类及其临床应用
- 批准号:
09670563 - 财政年份:1997
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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