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Influence of Serotonin Transporter Gene Polymorphism on Depressive Symptoms and New Cardiac Events after Acute Myocardial Infarction

Influence of Serotonin Transporter Gene Polymorphism on Depressive Symptoms and New Cardiac Events after Acute Myocardial Infarction
血清素转运蛋白基因多态性对急性心肌梗死后抑郁症状及新发心脏事件的影响
批准号:
15590743
负责人:
SATO Hiroshi
金额:
$2.18万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2003
资助国家:
日本
项目状态:
已结题
起止时间:
2003 至 2004

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中文摘要
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英文摘要
To investigate whether the S allele was associated with depressive symptoms and cardiac events after AMI, we prospectively examined depressive symptoms and new cardiac events in 2,509 genotyped AMI patients.Depressive symptoms were more common in patients with the S allele than in those without it (48.3% vs. 35.0%, P=0.02). Multivariate analysis revealed that the S allele was independently associated with depressive symptoms (odds ratio, 2.19; 95% CI, 1.21 to 3.98, P=0.01). Cardiac events (cardiac death, revascularization, heart failure, reinfarction, arrhythmia, and unstable angina) were more frequent in patients with the S allele than in those without it (31.3% vs. 22.3%, P=-0.046). Multivariate Cox regression analysis revealed an association between the S allele and increased risk of cardiac events (hazard ratio (HR), 1.69; 95% CI, 1.03 to 2.78; P=0.04). However, the HR became unsignificant after adjustment for depressive symptoms (HR; 1.30, 95% Ch 0.84 to 2.01, P=0.24).The S allele in the 5-HTTLPR is associated with an increased risk of subsequent cardiac events which is mediated, at least in part, by the depressive symptoms in patients after AMI.
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会议论文
Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study)
来自 52 个国家的 11119 例病例和 13648 名对照者的心理社会危险因素与急性心肌梗死风险的关联(INTERHEART 研究)
DOI: --
发表时间: 2004
期刊: Lancet 364(9438)
影响因子: --
作者: [Rosengren A, Sato H, et al.]
通讯作者: et al.
DOI: 10.1016/s0002-9149(03)00106-1
发表时间: 2003-04-15
期刊: AMERICAN JOURNAL OF CARDIOLOGY
影响因子: 2.8
作者: [Kinjo, K, Sato, H, Hori, M]
通讯作者: Hori, M
DOI: 10.1253/circj.68.809
发表时间: 2004-09-01
期刊: CIRCULATION JOURNAL
影响因子: 3.3
作者: [Kinjo, K, Sato, H, Hori, M]
通讯作者: Hori, M
DOI: 10.1016/j.amjcard.2003.07.021
发表时间: 2003-11-15
期刊: AMERICAN JOURNAL OF CARDIOLOGY
影响因子: 2.8
作者: [Kinjo, K, Sato, H, Hori, M]
通讯作者: Hori, M
15
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