Influence of Serotonin Transporter Gene Polymorphism on Depressive Symptoms and New Cardiac Events after Acute Myocardial Infarction

血清素转运蛋白基因多态性对急性心肌梗死后抑郁症状及新发心脏事件的影响

• 批准号: 15590743
• 负责人: SATO Hiroshi
• 金额: $ 2.18万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590743/
• 关键词: acute myocardial infarction; depressive sympton; serotonin transporter; gene polymorphism; long-term prognosis

To investigate whether the S allele was associated with depressive symptoms and cardiac events after AMI, we prospectively examined depressive symptoms and new cardiac events in 2,509 genotyped AMI patients.Depressive symptoms were more common in patients with the S allele than in those without it (48.3% vs. 35.0%, P=0.02). Multivariate analysis revealed that the S allele was independently associated with depressive symptoms (odds ratio, 2.19; 95% CI, 1.21 to 3.98, P=0.01). Cardiac events (cardiac death, revascularization, heart failure, reinfarction, arrhythmia, and unstable angina) were more frequent in patients with the S allele than in those without it (31.3% vs. 22.3%, P=-0.046). Multivariate Cox regression analysis revealed an association between the S allele and increased risk of cardiac events (hazard ratio (HR), 1.69; 95% CI, 1.03 to 2.78; P=0.04). However, the HR became unsignificant after adjustment for depressive symptoms (HR; 1.30, 95% Ch 0.84 to 2.01, P=0.24).The S allele in the 5-HTTLPR is associated with an increased risk of subsequent cardiac events which is mediated, at least in part, by the depressive symptoms in patients after AMI.

为了研究S等位基因是否与AMI后抑郁症状和心脏事件相关，我们前瞻性地检测了2,509例基因型AMI患者的抑郁症状和新发心脏事件，结果显示，携带S等位基因的患者抑郁症状比不携带S等位基因的患者更常见（48.3%比35.0%，P=0.02）。多因素分析显示，S等位基因与抑郁症状独立相关（比值比，2.19; 95%CI，1.21至3.98，P=0.01）。心脏事件（心源性死亡、血运重建、心力衰竭、再梗死、心律失常和不稳定型心绞痛）在携带S等位基因的患者中比不携带S等位基因的患者更常见（31.3% vs. 22.3%，P=-0.046）。多变量考克斯回归分析显示S等位基因与心脏事件风险增加相关（风险比（HR），1.69; 95%CI，1.03 - 2.78; P=0.04）。然而，在调整抑郁症状后，HR变得不显著（HR; 1.30，95%Ch 0.84至2.01，P=0.24）。5-HTTLPR中的S等位基因与随后心脏事件的风险增加相关，这至少部分是由AMI后患者的抑郁症状介导的。

项目成果

Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study)

来自 52 个国家的 11119 例病例和 13648 名对照者的心理社会危险因素与急性心肌梗死风险的关联（INTERHEART 研究）

• 发表时间: 2004
• 期刊: Lancet 364(9438)
• 作者: Rosengren A;Sato H;et al.
• 通讯作者: et al.

Impact of high-sensitivity C-reactive protein on predicting long-term mortality of acute myocardial infarction

• DOI: 10.1016/s0002-9149(03)00106-1
• 发表时间: 2003-04-15
• 期刊: AMERICAN JOURNAL OF CARDIOLOGY
• 影响因子: 2.8
• 作者: Kinjo, K;Sato, H;Hori, M
• 通讯作者: Hori, M

Predictors of length of hospital stay after acute myocardial infarction in Japan

• DOI: 10.1253/circj.68.809
• 发表时间: 2004-09-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Kinjo, K;Sato, H;Hori, M
• 通讯作者: Hori, M

Prognostic significance of atrial fibrillation/atrial flutter in patients with acute myocardial infarction treated with percutaneous coronary intervention

• DOI: 10.1016/j.amjcard.2003.07.021
• 发表时间: 2003-11-15
• 期刊: AMERICAN JOURNAL OF CARDIOLOGY
• 影响因子: 2.8
• 作者: Kinjo, K;Sato, H;Hori, M
• 通讯作者: Hori, M

Nakatani D, Sato H et al.: "Effect of successful late reperfusion by primary coronary angioplasty on mechanical complications of acute myocardial infarction"Am J Cardiol.. 92・7. 785-788 (2003)

Nakatani D、Sato H 等：“初次冠状动脉成形术成功的晚期再灌注对急性心肌梗死机械并发症的影响”Am J Cardiol.. 92・788 (2003)。