Influence of Serotonin Transporter Gene Polymorphism on Depressive Symptoms and New Cardiac Events after Acute Myocardial Infarction

点击翻译按钮获取中文摘要

To investigate whether the S allele was associated with depressive symptoms and cardiac events after AMI, we prospectively examined depressive symptoms and new cardiac events in 2,509 genotyped AMI patients.Depressive symptoms were more common in patients with the S allele than in those without it (48.3% vs. 35.0%, P=0.02). Multivariate analysis revealed that the S allele was independently associated with depressive symptoms (odds ratio, 2.19; 95% CI, 1.21 to 3.98, P=0.01). Cardiac events (cardiac death, revascularization, heart failure, reinfarction, arrhythmia, and unstable angina) were more frequent in patients with the S allele than in those without it (31.3% vs. 22.3%, P=-0.046). Multivariate Cox regression analysis revealed an association between the S allele and increased risk of cardiac events (hazard ratio (HR), 1.69; 95% CI, 1.03 to 2.78; P=0.04). However, the HR became unsignificant after adjustment for depressive symptoms (HR; 1.30, 95% Ch 0.84 to 2.01, P=0.24).The S allele in the 5-HTTLPR is associated with an increased risk of subsequent cardiac events which is mediated, at least in part, by the depressive symptoms in patients after AMI.