EFFECTS OF EXAGGERATED BLOOD PRESSURE VARIABILITY ON CARDIAC REMODELING AND PERIVASCULAR INFLAMMATION

(1)To为了阐明大范围血压变异性导致高血压器官损害的机制，我们通过对自发性高血压大鼠（SHR）进行双侧去窦主动脉神经（SAD）建立了一种新的大范围血压变异性高血压动物模型。(2)In SHR+SAD组平均血压升高至与SHR+假手术组相似水平。而SHR+SAD组血压变异性参数（平均血压标准差和平均血压变异系数）明显大于SHR+假手术组。（3）SHR+SAD组左室肥厚和心肌纤维化程度较SHR+Sham组明显加重。（4）SAD可显著上调SHR心肌MCP-1表达，增加心肌血管周围巨噬细胞浸润。

(1)To clarify the mechanism whereby wide blood pressure variability induces exaggerated hypertensive organ damages, we created new animal model of hypertension with large blood pressure variability by performing bilateral sino-aortic denervation(SAD) in spontaneously hypertensive rats(SHRs).(2)In SHR+SAD, mean blood pressure elevated to the similar level to that in SHR+sham operation. However, parameters of blood pressure variability, such as standard deviation of mean blood pressure and coefficent of variation of mean blood pressure, were significantly larger in SHR+SAD than in SHR+sham operation.(3)SHR+SAD had enhanced left ventricular hypertrophy and severer myocardial fibrosis, compared with SHR+sham operetion.(4)SAD remarkably upregulated myocardial MCP-1 expression and enhanced perivascular macrophage infiltration in the hearts of SHR.