Analysis of molecular mechanism of GH effect on life span

GH影响寿命的分子机制分析

• 批准号: 15591078
• 负责人: FUJIEDA Kenji
• 金额: $ 2.11万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591078/
• 关键词: Life Span; GH; Insulin; Forkhead transcription factor; IGF

The role of Foxolin GH-mediated life span was analyzed by comparing life span in the mice with GHR-/-and GHR-/-Foxo1-/-. Increase of body weight in Ghr-/-Foxo1+/-mice was much more remarkable than in GHR-/-mice, indicating that Foxo1 may play an important role in the signaling cascade of IGF system under the GH deficient condition.Secondly, the role of Foxo1 on glucose metabolism was examined. Blood glucose profile in mice with Ghr-/-Foxo1+/-at the age of 2,4 and 6 months was significantly lower than in Ghr-/-mice. Plasma insulin level significantly decreased in male mice with Ghr-/-Foxo1+/-than Ghr-/-mice. This was not observed in female mice. These findings suggest that Ghr-/-Foxo1+/-mice manifests increased insulin sensitivity. However, sex difference was present in increased insulin sensitivity. It is interesting to know from now how body weight and insulin sensitivity change with advancing age and how is a life span.

通过比较具有GHR-/-和GHR-/-Foxo 1-/-的小鼠的寿命来分析Foxolin GH介导的寿命的作用。Ghr-/-Foxo 1 +/-小鼠的体重增长明显高于GHR-/-小鼠，提示Foxo 1可能在GH缺乏条件下IGF系统的信号级联中起重要作用。其次，研究了Foxo 1在葡萄糖代谢中的作用。Ghr-/-Foxo 1 +/-小鼠在2、4和6月龄时的血糖谱显著低于Ghr-/-小鼠。Ghr-/-Foxo 1 +/-小鼠的血浆胰岛素水平显著低于Ghr-/-小鼠。这在雌性小鼠中未观察到。这些发现表明Ghr-/-Foxo 1 +/-小鼠表现出增加的胰岛素敏感性。但胰岛素敏感性增加存在性别差异。从现在开始了解体重和胰岛素敏感性如何随着年龄的增长而变化以及寿命如何是很有趣的。

项目成果

A case of achodroplasia associated with cervicomedullary junction compression

颈髓连接部受压导致软骨发育不全一例

• 发表时间: 2003
• 期刊: Clin Pediatr Endocrinol 12
• 作者: Takezaki T;Fujieda K et al.
• 通讯作者: Fujieda K et al.

Studies of Very Severe Short Stature with Severe GH Deficiency:From the Data Registered with the Foundation for Growth Science

严重身材矮小伴严重 GH 缺乏的研究：来自生长科学基金会注册的数据

• 发表时间: 2005
• 期刊: Endocr J 52
• 作者: Hanew K;et. al.
• 通讯作者: et. al.

Takezaki T: "A case of achondroplasia and associated with cervicomedullary-junction compression"Clin Pediatr Endocrinol.. 12. 39-42 (2003)

Takezaki T：“软骨发育不全与颈髓连接处受压相关的一例”Clin Pediatr Endocrinol.. 12. 39-42 (2003)

Studies of very short stature with severe GH deficiency : From the data registered with the foundation for growth science.

严重 GH 缺乏症的身材矮小研究：来自生长科学基金会登记的数据。

• 发表时间: 2005
• 期刊: Endocrine J. 52・1
• 作者: Hanew K^*;Tachibana K;Yokoya S;Fujieda K;Tanaka T;Igarashi Y;Shimatsu A;Tanaka H;Taniozawa T;Teramoto A;Nishi Y;Hasegawa Y;Hizuka N;Hirano T;Fujita K
• 通讯作者: Fujita K

内分泌疾患原因遺伝子の解明-成長に関わる遺伝子とその異常

阐明导致内分泌疾病的基因 - 生长相关基因及其异常

• 发表时间: 2003
• 期刊: 医学の歩み 206
• 作者: Takezaki T;Fujieda K et al.;藤枝憲二
• 通讯作者: 藤枝憲二