MULTIMODAL IMAGING OF THE SENSORY GATING DEFICIT IN SCHIZOPHRENIA

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本项目的最初目的是评估时间和空间完整性（即，通过研究对基本听觉刺激的电磁（脑磁图; MEG）和血流动力学（功能性磁共振成像; FMRI）反应，对精神分裂症（SP）患者和健康对照（HC）的听觉注意网络进行了研究。使用了不同的范例。第一个范例检查被动注意反应对相同和不相同的音调，以及单音（功能磁共振成像）。第二个范式研究了患者和控制者如何根据听觉线索和目标（功能磁共振成像和脑磁图）主动分配注意力资源到个人外空间。此外，我们还提出了检查的基础听觉注意，临床表现的认知测试和单核苷酸多态性之间的关系的成像标记。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The initial aims of the current project were to evaluate the temporal and spatial integrity (i.e., connectivity) of the auditory attention network in patients with schizophrenia (SP) and healthy controls (HC) by studying the electromagnetic (magnetoencephalogram; MEG) and hemodynamic (functional magnetic resonance imaging; FMRI) response to basic auditory stimuli. To different paradigms were utilized. The first paradigm examined passive attentional responses to pairs of identical and non-identical tones, as well single tones (FMRI only). The second paradigm examined how patients and controls actively allocate attentional resources to extrapersonal space based on auditory cues and targets (FMRI and MEG). In addition, we also proposed to examine the relationship between imaging markers of basic auditory attention, clinical performance on cognitive testing and single nucleotide polymorphisms.