MULTIMODAL IMAGING OF THE SENSORY GATING DEFICIT IN SCHIZOPHRENIA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 本项目的最初目的是通过研究精神分裂症患者(SP)和健康对照组(HC)的电磁(脑磁图；脑磁图)和血流动力学(功能磁共振成像；fMRI)对基本听觉刺激的反应来评估听觉注意网络的时间和空间完整性(即连通性)。采用了不同的研究范式。第一个范式考察了对相同和不相同的音调对以及单音的被动注意反应(仅限功能磁共振成像)。第二种范式考察了患者和控制者如何根据听觉线索和目标将注意力资源主动分配到个人外空间(fMRI和MEG)。此外，我们还建议研究基础听觉注意的影像指标、认知测试的临床表现和单核苷酸多态之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The initial aims of the current project were to evaluate the temporal and spatial integrity (i.e., connectivity) of the auditory attention network in patients with schizophrenia (SP) and healthy controls (HC) by studying the electromagnetic (magnetoencephalogram; MEG) and hemodynamic (functional magnetic resonance imaging; FMRI) response to basic auditory stimuli. To different paradigms were utilized. The first paradigm examined passive attentional responses to pairs of identical and non-identical tones, as well single tones (FMRI only). The second paradigm examined how patients and controls actively allocate attentional resources to extrapersonal space based on auditory cues and targets (FMRI and MEG). In addition, we also proposed to examine the relationship between imaging markers of basic auditory attention, clinical performance on cognitive testing and single nucleotide polymorphisms.