MULTIMODAL IMAGING OF THE SENSORY GATING DEFICIT IN SCHIZOPHRENIA

精神分裂症感觉门控缺陷的多模态成像

• 批准号: 8360222
• 负责人: Andrew Robert Mayer
• 金额: $ 24.88万
• 依托单位: THE MIND RESEARCH NETWORK
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360222
• 关键词: Attention; Auditory; Clinical; Cognitive; Controlled Study; Cues; Electromagnetics; Functional Magnetic Resonance Imaging; Funding; Grant; Image; Multimodal Imaging; National Center for Research Resources; Patients; Performance; Principal Investigator; Research; Research Infrastructure; Resources; Schizophrenia; Single Nucleotide Polymorphism; Source; Testing; United States National Institutes of Health; auditory stimulus; base; cost; hemodynamics; magnetoencephalogram; neuroimaging; neuromechanism; response; sensory gating; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The initial aims of the current project were to evaluate the temporal and spatial integrity (i.e., connectivity) of the auditory attention network in patients with schizophrenia (SP) and healthy controls (HC) by studying the electromagnetic (magnetoencephalogram; MEG) and hemodynamic (functional magnetic resonance imaging; FMRI) response to basic auditory stimuli. To different paradigms were utilized. The first paradigm examined passive attentional responses to pairs of identical and non-identical tones, as well single tones (FMRI only). The second paradigm examined how patients and controls actively allocate attentional resources to extrapersonal space based on auditory cues and targets (FMRI and MEG). In addition, we also proposed to examine the relationship between imaging markers of basic auditory attention, clinical performance on cognitive testing and single nucleotide polymorphisms.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 当前项目的最初目标是通过研究对基本听觉刺激的电磁（脑磁图；MEG）和血流动力学（功能磁共振成像；FMRI）反应，评估精神分裂症患者（SP）和健康对照（HC）听觉注意网络的时间和空间完整性（即连通性）。使用了不同的范式。第一个范式检查了对相同和不同音调以及单音调的被动注意力反应（仅 FMRI）。第二个范式研究了患者和对照者如何根据听觉线索和目标（FMRI 和 MEG）主动将注意力资源分配到个人外空间。此外，我们还建议检查基本听觉注意力的影像标记、认知测试的临床表现和单核苷酸多态性之间的关系。