Radiofrequency ablation with intratumoral injection of magnetic substance

瘤内注射磁性物质的射频消融术

• 批准号: 15591309
• 负责人: TANIGAWA Noboru
• 金额: $ 2.24万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591309/
• 关键词: Radiofrequency ablation; Magnetic substance; Induced electricity; 高周波熱凝固療法

Basic experiment under the sake which investigates the change of solidification range by the intratumoral magnetic substance injection was performed. The radiofrequency needle 17G and non-insulation length 2cm is inserted in the albumen, and it performed by the change of an output of the high frequency energization experiment. The diameter of solidification region in the fixed time was measured, while the solidification of the albumen is observed. Next, magnetic substance (molecular formula : γ-Fe2O2/C6H11O6-(C6H10O5)n-C6H11O5) which contained the iron which is a magnetic substance in the albumen was mixed, and the experiment was enforced by the similar experimental system. The largest solidification range is obtained the result at high frequency output 30W, and it obtained the solidification region 1.8-2.3cm.Referring to these results, the energization was enforced in the group which was entrapped in albumen group and albumen by the optimum experimental system in magnetic substance.As the result, in the group which injected magnetic substance 864mg (iron:44.6 mg) into the albumen, the solidification range expanded in comparison with the group only of the albumen early, and the rise over 10 Ω could not be recognized hoop and resistance value from energization start point of time. In addition, solidification range expanded in the albumen which injected magnetic substance 1728mg (iron:89.2 mg) of the multiple in the short time, and the resistance value was obtained in 9 minutes, and the rise over 10 Ω was obtained from the energization start.After magnetic substance was endermically injected, when it saw in the pulmonary tissue of the pig, basic experiment identical high frequency heat coagulation therapy, the wide coagulative necrosis was obtained by the cauterization in short time.

进行了研究肿瘤内磁性物质注射凝固范围变化的基础实验。将射频针17G、非绝缘长度2cm插入蛋白内，通过高频通电的输出的变化进行实验。测量固定时间内凝固区域的直径，同时观察蛋白的凝固情况。接下来，将蛋白中含有作为磁性物质的铁的磁性物质(分子式：γ-Fe 2 O 2 /C 6 H 11 O 6 -(C 6 H 10 O 5 ) n -C 6 H 11 O 5 )混合，通过同样的实验系统进行实验。最大凝固范围是在高频输出30W下获得的结果，并且获得了1.8-2.3cm的凝固区域。参考这些结果，通过磁性物质中的最佳实验系统在蛋白组和蛋白被捕获的组中强制通电。结果，在将磁性物质864mg(铁：44.6mg)注入蛋白中的组中，与对照组相比，凝固范围扩大了。 早期只有蛋白组，并且从通电开始时间点起超过10Ω的上升无法识别箍和电阻值。另外，在短时间内多次注射磁性物质1728mg(铁：89.2mg)的蛋白中，凝固范围扩大，9分钟内获得电阻值，从通电开始起获得了10Ω以上的上升。皮下注射磁性物质后，在猪的肺组织中看到与基础实验相同的高频热凝固疗法时，广泛的凝固 通过短时间烧灼实现坏死。