New embolic substance made by non biological material

非生物材料制成的新型栓塞物质

• 批准号: 17591299
• 负责人: TANIGAWA Noboru
• 金额: $ 2.43万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591299/
• 关键词: embolic material; PVA; embolization; 血管塞栓術

To evaluate the embolic effect, the tissue reaction, and the absorption of water-soluble polyvinyl alcohol (PVA) particles in renal arteries of pigs.Materials/Methods : Water-soluble PVA were specially made for this study. The chemical and physical properties of these round-shaped particles are : polymerization degree : 300, saponification degree : 97 and 99%, diameter range : 150-212 μm. The solubility of PVA into water was adjusted by the saponification degree. PVA (1 g in 5 ml of water-soluble contrast medium) was injected via a microcathter into the renal artery of pigs. Occlusion time was evaluated on angiography, and tissue reaction and absorption were evaluated by pathological examination.Results : Occlusion time on angiography was 30 minutes and three weeks with PVA saponification degrees at 97 and 99%, respectively. On histopathology, there was no residual embolization or severe foreign body reaction in the renal artery occluded with either PVA.Conclusion : Water-soluble PVA particles are an efficient temporary embolic material, since they block blood vessels without major tissue reactions, and their absorption can be controlled by adjusting their chemical properties.

目的：评价水溶性聚乙烯醇(PVA)颗粒在猪肾动脉内的栓塞效果、组织反应及吸收情况。材料/方法：本研究制备了水溶性PVA颗粒。聚合度为30 0，皂化度为97%和99%，粒径范围为15 0~2 12μm，可根据皂化度调节聚乙烯醇在水中的溶解。将PVA(1g/5ml水溶造影剂)经微导管注入猪肾动脉。结果：血管造影显示闭塞时间为30min，PVA皂化度为97%，闭塞时间为3周。在组织病理学上，PVA或PVA阻塞的肾动脉未见残留栓塞物或严重异物反应。结论：水溶性PVA颗粒堵塞血管，无明显组织反应，可通过调节其化学性质来控制其吸收，是一种有效的暂时性栓塞剂。