New embolic substance made by non biological material

探讨水溶性聚乙烯醇（PVA）颗粒在猪肾动脉内的栓塞作用、组织反应及吸收情况。材料/方法：为本研究专门配制水溶性聚乙烯醇。这些圆形颗粒的化学物理性能为：聚合度为300，皂化度为97和99%，粒径范围为150 ~ 212 μm。PVA在水中的溶解度受皂化程度的影响。将PVA （1 g溶于5 ml水溶性造影剂中）通过微导管注入猪肾动脉。血管造影评价封堵时间，病理检查评价组织反应和吸收。结果：血管造影封堵时间为30分钟，PVA皂化度为97%，封堵时间为3周。经组织病理学检查，两种PVA闭塞的肾动脉均未见残留栓塞或严重的异物反应。结论：水溶性PVA颗粒可阻断血管而不发生重大组织反应，可通过调节其化学性质来控制其吸收，是一种有效的临时栓塞材料。

To evaluate the embolic effect, the tissue reaction, and the absorption of water-soluble polyvinyl alcohol (PVA) particles in renal arteries of pigs.Materials/Methods : Water-soluble PVA were specially made for this study. The chemical and physical properties of these round-shaped particles are : polymerization degree : 300, saponification degree : 97 and 99%, diameter range : 150-212 μm. The solubility of PVA into water was adjusted by the saponification degree. PVA (1 g in 5 ml of water-soluble contrast medium) was injected via a microcathter into the renal artery of pigs. Occlusion time was evaluated on angiography, and tissue reaction and absorption were evaluated by pathological examination.Results : Occlusion time on angiography was 30 minutes and three weeks with PVA saponification degrees at 97 and 99%, respectively. On histopathology, there was no residual embolization or severe foreign body reaction in the renal artery occluded with either PVA.Conclusion : Water-soluble PVA particles are an efficient temporary embolic material, since they block blood vessels without major tissue reactions, and their absorption can be controlled by adjusting their chemical properties.