Experimental study on pain reduction mechanism of vertebroplasty for painful vertebral compression fracture

椎体成形术治疗痛性椎体压缩性骨折减痛机制的实验研究

• 批准号: 20602010
• 负责人: TANIGAWA Noboru
• 金额: $ 2.83万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20602010/
• 关键词: 疼痛学; 圧迫骨折; 椎体形成術

In order to clarify the mechanism of the pain reduction of percutaneous vertebroplasty (Bone cement injection method) the animal experiments described below were performed. The vertebral compression fractures were made for the pigs, and three kinds of treatments were enforced to the compression fractures. That is, the cement injection, the bone punch formation, and the wire fixation were performed, and the difference of the therapeutic effect was observed. The bone punch formation group achieved only the effect equal with the treatment free group when judged from the result of obtaining from the image result and pig's breeding situation overall. Moreover, the metal wire treatment became equal to the bone cement treatment after the fourth day, though the initial therapeutic effect was excellent. Therefore, it turned out that the fixation with the wire or the bone cement more effective than the decompression of the vertebral body.

为了阐明经皮椎体成形术（骨水泥注射法）减轻疼痛的机制，进行了下述动物实验。制作猪椎体压缩性骨折模型，对压缩性骨折进行三种不同的治疗。即，进行骨水泥注射、骨穿孔形成和钢丝固定，并观察治疗效果的差异。当从图像结果和猪的繁殖情况总体上获得的结果判断时，骨穿孔形成组仅获得了与无处理组相等的效果。此外，金属丝治疗在第四天后变得与骨水泥治疗相等，尽管初始治疗效果很好。因此，事实证明，用钢丝或骨水泥固定比椎体减压更有效。

项目成果

Prospective analysis of respiratory function following percutaneous vertebroplasty for osteoporotic compression fractures.

骨质疏松性压缩骨折经皮椎体成形术后呼吸功能的前瞻性分析。

• 发表时间: 2010
• 作者: Tanigawa N;et al
• 通讯作者: et al

Prospective analysis of respiratory function following percutaneous vertebroplasty for osteoporotic compression fractures

骨质疏松性压缩骨折经皮椎体成形术后呼吸功能的前瞻性分析

• 发表时间: 2010
• 作者: Tanigawa N;et al
• 通讯作者: et al

Cement leakage in percutaneous vertebroplasty for osteoporotic compression fracture with or without intravertebral clefts.

经皮椎体成形术治疗伴或不伴椎体内裂的骨质疏松性压缩骨折中的骨水泥渗漏。

• 发表时间: 2009
• 期刊: Am J Roentgenol 193(5)
• 作者: Tanigawa N;Kariya S;Komemushi A;Tokuda T;Nakatani M;Yagi R;Sawada S
• 通讯作者: Sawada S

Cement leakage in percutaneous vertebroplasty for osteoporotic compression fracture with or without intravertebral clefts

经皮椎体成形术治疗伴或不伴椎体裂的骨质疏松性压缩骨折中骨水泥渗漏

• 发表时间: 2009
• 期刊: Am J Roentgenol 193
• 作者: Tanigawa N;et al
• 通讯作者: et al

Improvement in respiratory function by percutaneous vertebroplasty

• DOI: 10.1080/02841850802010758
• 发表时间: 2008-07
• 期刊: Acta Radiologica
• 影响因子: 1.3
• 作者: Noboru Tanigawa;S. Kariya;H. Kojima;A. Komemushi;Yuzo Shomura;T. Tokuda;Y. Ueno;S. Kuwata;A. Fujita;Jiro Terada;Satoshi Sawada