New strategy of metallic stent therapy with radiofrequency

可扩张金属支架的置入可解除恶性肿瘤引起的管腔器官的梗阻性病变，广泛应用于气道、消化道、血管等恶性狭窄病变。然而，支架本身仅物理扩张狭窄的管腔器官。随着时间的推移，肿瘤局部发展到支架的内腔（肿瘤向内生长）或支架的远端和近端（肿瘤过度生长），并且局部病变必然迫使再狭窄。同时，从体外对支架施加射频（感应和加温），使支架产生分离的热，并进行热增强抗肿瘤作用的动物实验，将可膨胀金属支架置入日本白色家兔气管内。将家兔置于感应加热系统中，从体外进行感应加热，测量支架周围管道组织的温度变化。在400W时，支架周围温度随时间推移而升高，3min后达到平台，5min后为41.29℃。在600W功率下，家兔在4min后体温升高达到平台，5min后体温为51.85℃。在800W的家兔中，1分30秒后达到48℃。通过在支架放置后以600W的输出通电，比它们更有可能将组织加热到获得抗肿瘤效果的温度。

A release of obstructive lesion of the luminal organ which originates from the malignant tumor can be achieved by the placement of the expandable metallic stent, and it is widely applied in the malignant stenotic lesion such as airway, digestive tract, vessels. However, the stent itself only physically expands stenoic luminal organ. The tumor locally develops to the inner lumen of the stent (tumor ingrowth) or distal and proximal end of the stent (tumor overgrowth) with the progress in the time, and the local lesion consequentially forces restenosis. In the time, a heat was detachedly generated by the radiofrequency (the induction and warming) added to the stent from extracorporeal, and the animal test which added antitumor effect by the heat was enforced.Expandable metallic stent was inserted in the trachea of Japanese white rabbits. The rabbit was installed in the induction heating system, and the induction warming was enforced from extracorporeal, and the temperature change of tract tissue around the stent was measured. In 400W, the temperature of the stent circumference rose with the time course, and it reached the plateau from after 3 minutes, and the temperature after 5 minutes was 41.29℃. In 600W rabbit, the temperature rise reaches the plateau after 4 minutes, and the temperature after 5 minutes was 51.85℃. In 800W rabbit, it reached 48℃ after 1 minute 30 seconds. By energizing at output 600W after the stent placement, it was more possible to heat the organization to the temperature of which the antitumor effect is obtained than them.