New strategy of metallic stent therapy with radiofrequency

可膨胀金属支架的置入可以实现对起源于恶性肿瘤的腔器官梗阻性病变的解除，广泛应用于呼吸道、消化道、血管等恶性狭窄病变。然而，支架本身仅在物理上扩张狭窄的管腔器官。随着时间的推移，肿瘤局部发展到支架的内腔(肿瘤向内生长)或支架的远、近端(肿瘤过度生长)，局部病变导致再狭窄。在此期间，从体外向支架中加入射频(诱导和升温)分别产生热量，并实施通过热量增加抗肿瘤作用的动物实验。将可膨胀金属支架植入日本大白兔的气管内。将兔安装在感应加热系统中，从体外强制感应升温，测量支架周围组织的温度变化。400W时，支架周围温度随时间延长而升高，3min后达到平台期，5min后温度为41.29℃。600W兔的温升在4分钟后达到平台期，5分钟后温度为51.85℃。800W兔在1分30秒后达到48℃。在支架放置后，通过在输出600W处通电，比它们更有可能将组织加热到获得抗肿瘤效果的温度。

A release of obstructive lesion of the luminal organ which originates from the malignant tumor can be achieved by the placement of the expandable metallic stent, and it is widely applied in the malignant stenotic lesion such as airway, digestive tract, vessels. However, the stent itself only physically expands stenoic luminal organ. The tumor locally develops to the inner lumen of the stent (tumor ingrowth) or distal and proximal end of the stent (tumor overgrowth) with the progress in the time, and the local lesion consequentially forces restenosis. In the time, a heat was detachedly generated by the radiofrequency (the induction and warming) added to the stent from extracorporeal, and the animal test which added antitumor effect by the heat was enforced.Expandable metallic stent was inserted in the trachea of Japanese white rabbits. The rabbit was installed in the induction heating system, and the induction warming was enforced from extracorporeal, and the temperature change of tract tissue around the stent was measured. In 400W, the temperature of the stent circumference rose with the time course, and it reached the plateau from after 3 minutes, and the temperature after 5 minutes was 41.29℃. In 600W rabbit, the temperature rise reaches the plateau after 4 minutes, and the temperature after 5 minutes was 51.85℃. In 800W rabbit, it reached 48℃ after 1 minute 30 seconds. By energizing at output 600W after the stent placement, it was more possible to heat the organization to the temperature of which the antitumor effect is obtained than them.