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New strategy of metallic stent therapy with radiofrequency

射频金属支架治疗新策略

基本信息

批准号：
13470191
负责人：
TANIGAWA Noboru
金额：
$ 2.3万
依托单位：
Kansai Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470191/
关键词：
Interventional Radiology Trachea Metallic stent Radiofrequency 誘導加温温熱療法

项目摘要

A release of obstructive lesion of the luminal organ which originates from the malignant tumor can be achieved by the placement of the expandable metallic stent, and it is widely applied in the malignant stenotic lesion such as airway, digestive tract, vessels. However, the stent itself only physically expands stenoic luminal organ. The tumor locally develops to the inner lumen of the stent (tumor ingrowth) or distal and proximal end of the stent (tumor overgrowth) with the progress in the time, and the local lesion consequentially forces restenosis. In the time, a heat was detachedly generated by the radiofrequency (the induction and warming) added to the stent from extracorporeal, and the animal test which added antitumor effect by the heat was enforced.Expandable metallic stent was inserted in the trachea of Japanese white rabbits. The rabbit was installed in the induction heating system, and the induction warming was enforced from extracorporeal, and the temperature change of tract tissue around the stent was measured. In 400W, the temperature of the stent circumference rose with the time course, and it reached the plateau from after 3 minutes, and the temperature after 5 minutes was 41.29℃. In 600W rabbit, the temperature rise reaches the plateau after 4 minutes, and the temperature after 5 minutes was 51.85℃. In 800W rabbit, it reached 48℃ after 1 minute 30 seconds. By energizing at output 600W after the stent placement, it was more possible to heat the organization to the temperature of which the antitumor effect is obtained than them.

可扩性金属支架的置入可使源自恶性肿瘤的腔内器官梗阻性病变得到释放，广泛应用于气道、消化道、血管等恶性狭窄病变。然而，支架本身只是物理扩张狭窄的管腔器官。随着时间的推移，肿瘤局部发展到支架内腔（肿瘤向内生长）或支架远端和近端（肿瘤过度生长），局部病变必然导致再狭窄。同时，通过体外注入支架的射频（感应和加热）分离产生热量，并通过热量增加抗肿瘤作用进行动物实验。将可膨胀金属支架置入日本大白兔气管内。将家兔置于感应加热系统中，从体外进行感应加热，测量支架周围气道组织的温度变化。400W时，支架周长温度随时间进程升高，3分钟后达到平稳，5分钟后温度为41.29℃。600W家兔，4分钟后温升达到高原，5分钟后温度为51.85℃。在800W家兔中，1分30秒后达到48℃。在支架置入后以600W的输出功率通电，更有可能将组织加热到达到抗肿瘤效果的温度。