权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Liver atrophy and Lipid metabolism after mesocaval and portocaval shunt in the rats

大鼠间腔静脉和门静脉分流术后的肝脏萎缩和脂质代谢

基本信息

批准号：
15591333
负责人：
ABE Hideki
金额：
$ 2.24万
依托单位：
TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591333/
关键词：
Mesocaval shunt Portocaval shunt Triglyceride Free fatty acid インスリン上腸間膜静脈下大静脈 TGSR:triglyceride secretion rate 高インスリン血症膵臓移植 TGSR : triglyceride secretion rate

项目摘要

Surgical splanchnic circulatory diversion into the systemic circulation, such as posrtocaval shunting or mesocaval shunting, has still been reported to treat bleeding esophageal varices caused by portal hypertension in the present era of liver transplantation. Even in liver transplanted recipients, surgical portosystemic shunting has been indicated to alleviate successfully portal hypertension, and in order to avoid graft congestion and failure by overperfusion in adult recipients using small-for-size partial liver graft. When a surgical portosystemic shunting is necessary in a patient with intrinsic liver disease, the possibility of future liver transplantation has to be considered. In liver transplanted recipients, however, surgical shunt cannot be closed whenever hepatic encephalopathy does not develop.Body weight of mesocaval shunt group did not significantly less increase in comparison with control group. While, liver weight of mesocaval shunt significantly less increased in comparison with control group. Triglyceride secretion rate of mesocaval shunt significalntly less increased in comparison with control group. Triglyceride secretion rate of mesocaval shunt significantly correlated with liver weight.

外科内脏循环转流术，如下腔静脉后分流术或肠系膜分流术，在目前的肝移植时代仍被报道用于治疗门静脉高压症所致的食道静脉曲张出血。即使在肝移植受者中，外科门体分流也被证明能成功缓解门脉高压，并在使用小体积部分肝移植的成人受者中避免移植物充血和因过度灌流而失败。当内源性肝病患者需要外科门体分流术时，必须考虑未来肝移植的可能性。然而，在肝移植受者中，只要没有发生肝性脑病，外科分流就不能关闭。与对照组相比，肠腔分流组的体重增加并没有明显减少。与对照组相比，肠腔分流术组大鼠肝脏重量增加明显减少。肠腔分流术组的甘油三酯分泌率明显低于对照组。肠腔分流术的甘油三酯分泌率与肝脏重量显著相关。