Liver atrophy and Lipid metabolism after mesocaval and portocaval shunt in the rats

在当前肝移植时代，仍有报道将外科移植循环分流至体循环，如腔后分流或腔内分流，用于治疗门静脉高压引起的出血性食管静脉曲张。即使在肝移植受者中，外科门静脉系统分流也被认为可以成功缓解门静脉高压症，并避免成人小尺寸部分肝移植受者因过度灌注而导致移植物充血和衰竭。当内源性肝病患者需要手术门静脉分流时，必须考虑未来肝移植的可能性。然而，在肝移植受者中，只要肝性脑病没有发生，手术分流就不能关闭。与对照组相比，中腔分流组体重的增加没有明显减少。与对照组相比，腹腔分流组肝脏重量明显增加。与对照组相比，腹腔分流组甘油三酯分泌率明显降低。腹腔分流甘油三酯分泌率与肝脏重量显著相关。

Surgical splanchnic circulatory diversion into the systemic circulation, such as posrtocaval shunting or mesocaval shunting, has still been reported to treat bleeding esophageal varices caused by portal hypertension in the present era of liver transplantation. Even in liver transplanted recipients, surgical portosystemic shunting has been indicated to alleviate successfully portal hypertension, and in order to avoid graft congestion and failure by overperfusion in adult recipients using small-for-size partial liver graft. When a surgical portosystemic shunting is necessary in a patient with intrinsic liver disease, the possibility of future liver transplantation has to be considered. In liver transplanted recipients, however, surgical shunt cannot be closed whenever hepatic encephalopathy does not develop.Body weight of mesocaval shunt group did not significantly less increase in comparison with control group. While, liver weight of mesocaval shunt significantly less increased in comparison with control group. Triglyceride secretion rate of mesocaval shunt significalntly less increased in comparison with control group. Triglyceride secretion rate of mesocaval shunt significantly correlated with liver weight.