Angiogenesis and Tumor Proliferation/Metastasis of Human Colorectal Cancer Cell Line SW620 Transfected with Endocrine Glands-Derived-Vascular Endothelial Growth Factor, As a New Angiogenic Factor

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Endocrine glands-derived-venous endothelial growth factor (EG-VEGF) was recently cloned as a new angiogenic factor that selectively acts on the endothelium of endocrine gland cells. The expression of EG-VEGF was comfirmed in all colorectal cancer cell lines. (On the other hand, the expression of EG-VEGF mRNA was not detected in colorectal normal mucosae.)Tumor proliferation(cecum, s.c.) was significantly higher in the EG-VEGF transfectants than in the control cells. Also, Liver metastatic ratio was higher in the EG-VEGF transfectants than in the control cells. In this study, EG-VEGF may lead to angiogenesis, promoting cell proliferation, and liver metastasis in colorectal cancers. And When the EG-VEGF gene-overexpressing colorectal cancer cell line had been treated with phosphorothioate antisense EG-VEGF oligonucleotides, angiogenesis and tumor growth were inhibited. Angiogenesis factor EG-VEGF indicates that it is a cancer-specific and possibly tissue-specific angiogenesis factor in the large intestine, and suggests that it can be targeted by a novel anti angiogenesis therapy.