Endobronchial targeting therapy using Perfluorocabon-mediated drug delivery system to lung neoplasm

使用全氟化碳介导的药物递送系统对肺肿瘤进行支气管内靶向治疗

• 批准号: 15591487
• 负责人: ENDO Shunsuke
• 金额: $ 2.11万
• 依托单位: JICHI MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591487/
• 关键词: drug delivery system; liquid ventilation; Perfluorocarbon; lung cancer; endobronchial therapy; 薬物運搬; ARDS; GFPラット; 白血球の活性化; ステロイド; フッ素化合物; 塩酸肺損傷; 液体呼吸

Survival rate of patients with lung cancer remains unsatisfied compared to those of patients with other neoplasms. Most of these patients died of respiratory insufficiency during lung cancer treatment based on such underlying lung diseases as pulmonary emphysema or interstitial pneumonia. Ideal lung cancer treatment should not induce any lung injury except lung cancer tissue. Perfluorocabon is a good agent as oxygen delivery with low surface tension and can be utilized as drug delivery agents selectively to lung cancer tisuue.We clarified efficacy of Perfluorocabon-mediated steroid delivery system to acute lung injury caused by hydrochloride instillation and endotoxin injection as a pilot study. In the second step, we evaluated utility of Perfluorocabon-mediated drug delivery system to lung neoplasm by means of metastatic Sato-lung cancer rat models. Microcirculation of lung cancer implanted after intravenously injection of Sato-lung cancer to Donryu-rat models was visualized via a fluorescent vital microscope. Microcirculatory disorders including sequestration of activated neutrophils occurred in the regions around metastatic lung cancer after intravenously injection of endotoxin. Perfluorocabon-mediated delivery system attenuated these microcirculatory disorders compared to those microcirculatory disorders without any treatments. In conclusion, the result suggested that Perfluorocabon-mediated drug delivery system can be clinically utilized in the lung cancer treatment.

与其他肿瘤患者相比，肺癌患者的生存率仍不令人满意。这些患者中的大多数在基于肺气肿或间质性肺炎等潜在肺部疾病的肺癌治疗期间死于呼吸功能不全。理想的肺癌治疗应不引起除肺癌组织以外的任何肺损伤。Perfluorocabon是一种良好的低表面张力氧载体，可作为肺癌组织的选择性给药载体，本研究通过对Perfluorocabon介导的类固醇给药系统治疗盐酸盐灌注和内毒素注射所致急性肺损伤的初步研究，阐明其对肺损伤的疗效。第二步，通过大鼠肺转移性Sato肺癌模型，评价全氟卡朋介导的药物传递系统对肺癌的治疗作用。通过荧光活体显微镜观察静脉注射佐藤肺癌至东柳大鼠模型后植入的肺癌的微循环。静脉注射内毒素后，转移性肺癌周围区域发生微循环障碍，包括活化的中性粒细胞的隔离。与未接受任何治疗的微循环障碍相比，全氟卡波介导的递送系统减轻了这些微循环障碍。结果表明，全氟卡巴介导的药物释放系统可用于肺癌的临床治疗。

项目成果

Thoraco-pleuropneumonectomy for Rupture of a Huge Chronic Hematoma of the Thorax

• DOI: 10.1007/s11748-005-0025-7
• 发表时间: 2005-03-01
• 期刊: GENERAL THORACIC AND CARDIOVASCULAR SURGERY
• 影响因子: 1.2
• 作者: Endo, Shunsuke;Hasegawa, Tsuyoshi;Sohara, Yasunori
• 通讯作者: Sohara, Yasunori

Endo S, et al.: "Tracheocele : Surgical and thoracoscopic findings."Ann Thorac Surg 2004. (in press). (2004)

Endo S 等人：“气管膨出：手术和胸腔镜检查结果。”Ann Thorac Surg 2004。（印刷中）。

Pulmonary cryptococcosis mimicking pulmonary metastases in a patient treated with tegafur-uracil after lung cancer surgery

肺癌术后接受替加氟-尿嘧啶治疗的患者出现类似肺转移的肺隐球菌病

• 发表时间: 2005
• 期刊: Jpn J Thorac Cardiovasc Surg 53
• 作者: Endo S;Saito N;Hasegawa T;Sato Y;Sohara Y.
• 通讯作者: Sohara Y.

末梢小型肺癌の臨床病理と縮小手術の可能性

周围型小肺癌的临床病理和减容手术的可能性

• 发表时间: 2004
• 期刊: 胸部外科 57
• 作者: Sato Y;Endo S;et al.;遠藤俊輔ほか
• 通讯作者: 遠藤俊輔ほか

Real-time visualization of partial liquid ventilation in a model of acute lung injury.

急性肺损伤模型中部分液体通气的实时可视化。

• 发表时间: 2003
• 期刊: Surgery 133
• 作者: Endo S;Sohara Y;Murayama F;Yamaguchi T;Hasegawa T;Kanai Y.
• 通讯作者: Kanai Y.