Endobronchial targeting therapy using Perfluorocabon-mediated drug delivery system to lung neoplasm

与其他肿瘤患者相比，肺癌患者的生存率仍不理想。这些患者大多在肺癌治疗过程中死于呼吸功能不全，原因是肺部基础疾病如肺气肿或间质性肺炎。理想的肺癌治疗不应引起除肺癌组织外的任何肺损伤。全氟碳化物是一种低表面张力的良好供氧剂，可选择性地作为肺癌组织的给药剂。我们初步研究了全氟碳素介导的类固醇给药系统对盐酸滴注和内毒素注射引起的急性肺损伤的疗效。在第二步，我们通过转移性佐藤肺癌大鼠模型评估了全氟碳化物介导的药物传递系统对肺肿瘤的效用。采用荧光生命显微镜观察经静脉注射佐藤肺癌植入东流大鼠模型后肺癌微循环的变化。在静脉注射内毒素后，转移性肺癌周围区域出现微循环障碍，包括活化中性粒细胞的隔离。与未经任何治疗的微循环疾病相比，全氟碳化物介导的递送系统减轻了这些微循环疾病。综上所述，全氟碳化物介导的给药系统可用于肺癌的临床治疗。

Survival rate of patients with lung cancer remains unsatisfied compared to those of patients with other neoplasms. Most of these patients died of respiratory insufficiency during lung cancer treatment based on such underlying lung diseases as pulmonary emphysema or interstitial pneumonia. Ideal lung cancer treatment should not induce any lung injury except lung cancer tissue. Perfluorocabon is a good agent as oxygen delivery with low surface tension and can be utilized as drug delivery agents selectively to lung cancer tisuue.We clarified efficacy of Perfluorocabon-mediated steroid delivery system to acute lung injury caused by hydrochloride instillation and endotoxin injection as a pilot study. In the second step, we evaluated utility of Perfluorocabon-mediated drug delivery system to lung neoplasm by means of metastatic Sato-lung cancer rat models. Microcirculation of lung cancer implanted after intravenously injection of Sato-lung cancer to Donryu-rat models was visualized via a fluorescent vital microscope. Microcirculatory disorders including sequestration of activated neutrophils occurred in the regions around metastatic lung cancer after intravenously injection of endotoxin. Perfluorocabon-mediated delivery system attenuated these microcirculatory disorders compared to those microcirculatory disorders without any treatments. In conclusion, the result suggested that Perfluorocabon-mediated drug delivery system can be clinically utilized in the lung cancer treatment.