Development of new-designed device ("simultaneous transcranial measurement system of multiple electrical pulse impedances using multi-polar circuit method") to measure local cerebral blood flow

开发新设计的局部脑血流量测量装置（“使用多极电路法的多个电脉冲阻抗同时经颅测量系统”）

• 批准号: 15591516
• 负责人: NISHIZAWA Shigeru
• 金额: $ 2.24万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591516/
• 关键词: magnetic field; electrical impedance; cerebral blood flow; less invasive; tetra-polar circuit method

We newly designed and developed a system ("simultaneous transcranial measurement system of multiple electrical pulse impedances using multi-polar circuit method") to measure multi-point local cerebral blood flow. Actually, 8 points of local cerebral blood flow can be measured transcranially. The system rotates around the head and electrical impedance is measured at each point.We loaded three different kinds of task forces, such as light stimulation, loading of CO2, and pointing of difference between similar figures. In the test of pointing of difference between similar figures, impedance detected from bilateral temporo-occipital areas were significantly changed. In the light stimulation, such change was detected in occipital areas. In the loading of CO2, impedance change in the whole area was found.We tried these tests using animal model, and examined the impedance change, which was obtained in volunteers, would also found in the animal model, and also tested the relation between the impedance change and change of intracranial pressure. However, it took unexceptionally longer time to establish the same system for animal experiment, and we did not get good results in the animal experimental model yet.In near future, we will finish to produce the same system for animal experiment, and try this system to the experimental animal, and examine weather the results using this system for volunteers represent real change of local cerebral blood flow or not.

我们新设计并开发了一种多点局部脑血流测量系统（“多极电路法多脉冲阻抗同时经颅测量系统”）。实际上，可以经颅测量8个局部脑血流量点。该系统围绕头部旋转，并在每个点测量电阻抗。我们加载了三种不同的任务力，如光刺激，CO2加载，以及相似图形之间的差异指向。在相似图形间差异指向实验中，双侧颞枕区的阻抗值变化显著。在光刺激下，这种变化在枕区被检测到。在CO_2负荷下，整个脑区的阻抗都发生了变化，我们用动物模型进行了这些实验，检测了阻抗的变化，在志愿者中得到的阻抗变化也会在动物模型中得到，并检测了阻抗变化与颅内压变化的关系。但是，由于建立动物实验系统的时间较长，在动物实验模型中还没有得到很好的结果，我们将在不久的将来完成动物实验系统的制作，并对实验动物进行实验，检验志愿者使用该系统的结果是否代表真实的局部脑血流量的变化。