Research for producing the rapeutic agents on proteinkinase C to inhibit cerebral vasospasm following subarachnoid hemorrhage

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Cerebral vasospasm following subarachnoidhemorrhage(SAH)is an important factor to improve prognosis of the SAH patients. The mechanisms of cerebral vasospasm has still been unknown. PKCa and PKCd are most important candidates to produce cerebral vasospasm according to our own research results. The aim of this research is to search an inhibitor on both PKC isoforms and to produce therapeutic agents for inhibition of cerebral vasospasm. An inhibitor was found through the research, but production of therapeutic agent has no been available. Insertion of a catheter into subarachnoid space and continuous administration of the drug is considered to be a realistic way so far.