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Analysis of distribution of dihydrotestosterone concentration in prostate cancer tissue and differences of dihydrotestosterone and androgen induced gene expression after androgen deprivation

前列腺癌组织中二氢睾酮浓度分布及雄激素剥夺后二氢睾酮与雄激素诱导基因表达差异分析

基本信息

批准号：
15591683
负责人：
NISHIYAMA Hiroyuki
金额：
$ 2.24万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

Objectives : Molecular studies suggest that ethnicity influences prostate tumor biology. We evaluated multiple known prognostic markers in localized prostate cancers using tissue microarrays (TMA) in Japanese patients.Methods : Specimens were from 52 patients undergoing radical surgery at our institution between 1997 and 2001 without neoadjuvant hormonal therapy with complete 3 or more available cancer spots. Ki67, p53, and androgen receptor(AR) antigen expression were examined. Immunohistochemical scores were compared with outcomes of chemical relapse as monitored using prostate-specific antigen(PSA).Results : Pathologic tumor (T) classification (p=0.047), World Health Organization(WHO) score (p=0.026), WHO histologic grade (p=0.026), and surgical margin status (p=0.018) were significant conventional clinicopathologic variables for predicting biochemical failure. TMA Gleason sum (p=0.038), TMA primary Gleason grade (p=0.013), Ki67 labeling index (LI) (p<0.0001), p53 (p=0.0097), and AR (p=0.0113) antigen expression also were significant. Moreover, surgical margin status and Ki67 LI were independently associated with treatment failure.Conclusions : Especially together, Ki67 LI and p53 and AR expression in a localized prostate cancer often predicted postoperative progression in Japanese patients.

目的：分子研究表明，种族影响前列腺肿瘤生物学。我们评估了多个已知的预后标志物在本地化的前列腺癌组织微阵列（TMA）在日本patients.Methods：标本来自52例患者接受根治性手术在我们的机构在1997年和2001年之间没有新辅助激素治疗，完整的3个或更多可用的癌症斑点。检测Ki67、p53和雄激素受体（AR）抗原表达。结果：病理肿瘤（T）分类（p=0.047），世界卫生组织（WHO）评分（p= 0.026），WHO组织学分级（p = 0.026），手术切缘状态（p =0.018）是预测生化失败的重要传统临床病理变量。TMA Gleason总和（p=0.038）、TMA原发Gleason分级（p=0.013）、Ki67标记指数（LI）（p<0.0001）、p53（p=0.0097）和AR（p=0.0113）抗原表达也是显著的。此外，手术切缘状态和Ki67 LI独立相关治疗failure.Conclusions：特别是在一起，Ki67 LI和p53和AR表达在一个本地化的前列腺癌往往预测术后进展的日本患者。