Molecular mechanism of urothelium regulating bladder function
Molecular mechanism of urothelium regulating bladder function
批准号:
20390425
负责人:
NISHIYAMA Hiroyuki
金额:
$11.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
本研究旨在阐明刺激下膀胱分泌的分子改变膀胱功能的机制。我们结合传统的药理学分析、分子生物学分析和新的排尿行为分析,阐明了尿道功能障碍的生理作用和与尿道功能障碍相关的膀胱疾病的临床情况。
英文摘要
In this project, we engaged in clarification of the mechanism underlying change in bladder function with the molecules secreted from urothelium under stimuli. We demonstrated the physiological role of urothelium and the clinical condition of the bladder disease related with dysfunctional urothelium with combination of conventional pharmacological analysis, molecular biological analysis and new voiding behavior analysis.
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DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1152/ajprenal.00107.2007
发表时间:
2007-10-01
期刊:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
影响因子:
4.2
作者:
[Imamura, Masaaki, Kanematsu, Akihiro, Ogawa, Osamu]
通讯作者:
Ogawa, Osamu
Regulation of Connexin 43 by Basic Fibroblast Grwoth Factor in the Bladder : Transcriptional and Behavioral Implications.
膀胱中碱性成纤维细胞生长因子对连接蛋白 43 的调节:转录和行为影响。
DOI:
--
发表时间:
2011
期刊:
J Urol. 185
影响因子:
--
作者:
[Negoro H, Kanematsu A, Ogawa O, et al.]
通讯作者:
et al.
Basic fibroblast growth factor(bFGF) promotes bladder smooth muscle cell proliferation and matrix remodeling through ERK1/2 pathway.
碱性成纤维细胞生长因子(bFGF)通过ERK1/2途径促进膀胱平滑肌细胞增殖和基质重塑。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[今村 正明, 他, Imamura M. et.al.]
通讯作者:
Imamura M. et.al.
bFGFによる平滑筋gap junction発現を介した過活動膀胱発症機序の解明
阐明 bFGF 诱导的平滑肌间隙连接表达介导的膀胱过度活动症发病机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kobayashi T, Nishiyama H, Ogawa O., (他7名), 根来宏光]
通讯作者:
根来宏光
共 9 条
Development of antitumor immunological agent using mycobacterial surface glycolipids as lead compounds.
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批准号:18H02934
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.98万
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财政年份:2018
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负责人:NISHIYAMA Hiroyuki
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依托单位:
Development of bladder cancer early diagnosis and treatment method using the CXCR4-beta arrestin2-ERK pathway
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批准号:23592330
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2011
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负责人:NISHIYAMA Hiroyuki
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依托单位:
A STUDY OF THE EFFECT OF A BARRIER TO ECONOMIC DEVELOPMENT IN EAST ASIA
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批准号:22530234
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:2010
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负责人:NISHIYAMA Hiroyuki
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依托单位:
Analysis of distribution of dihydrotestosterone concentration in prostate cancer tissue and differences of dihydrotestosterone and androgen induced gene expression after androgen deprivation
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批准号:15591683
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:NISHIYAMA Hiroyuki
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依托单位:
海外基金