Development of bladder cancer early diagnosis and treatment method using the CXCR4-beta arrestin2-ERK pathway

利用CXCR4-β抑制蛋白2-ERK通路开发膀胱癌早期诊断和治疗方法

• 批准号: 23592330
• 负责人: NISHIYAMA Hiroyuki
• 金额: $ 3.24万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592330/
• 关键词: CXCR4; ARRB2; TXNIP; bladder; carcinogenesis; 尿路上皮癌; βarrestin2; 膀胱癌早期診断治療法; BBN; EMT; E cadherin

The result of gene and protein expression of CXCR4-ERK pathway and TXNIP-ARRB2 pathway in mouse bladder cancer model and bladder cancer cell lines. We indicate that TXNIP negatively regulates bladder carcinogenesis by attenuating SDF-1-CXCR4-induced ERK activation. This signal transductionpathway can be a potent target in preventing or treating bladder cancer.

CXCR 4-ERK通路和TXNIP-ARRB 2通路在小鼠膀胱癌模型和膀胱癌细胞系中基因和蛋白表达的结果。我们表明TXNIP通过减弱SDF-1-CXCR 4诱导的ERK激活来负性调节膀胱癌的发生。这一信号转导通路可能成为预防或治疗膀胱癌的有效靶点。

项目成果

The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1).

• DOI: 10.1371/journal.pone.0049709
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kajita Y;Kato T Jr;Tamaki S;Furu M;Takahashi R;Nagayama S;Aoyama T;Nishiyama H;Nakamura E;Katagiri T;Nakamura Y;Ogawa O;Toguchida J
• 通讯作者: Toguchida J

A novel animal model of underactive bladder : Analysis of lower urinary tract function in a rat lumbar canal stenosis model

新型膀胱活动不足动物模型：大鼠腰管狭窄模型下尿路功能分析

• DOI: 10.1002/nau.21255
• 发表时间: 2012
• 期刊: Neurourol Urodyn
• 作者: Sekido N;Joraku A;Okada H;Wakamatsu D;Matsuya H;Nishiyama H
• 通讯作者: Nishiyama H

Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy

VHL 无效透明细胞肾细胞癌中具有内皮开窗的肿瘤微血管作为抗血管生成治疗的有效靶点

• 发表时间: 2012
• 期刊: Cancer Sci
• 影响因子: 5.7
• 作者: Yamasaki T;Nishiyama H.
• 通讯作者: Nishiyama H.

Management of ureteral obstruction in advanced testicular tumor with lymph node metastasis

晚期睾丸肿瘤伴淋巴结转移输尿管梗阻的处理

• DOI: 10.1093/jjco/hys094
• 发表时间: 2012
• 期刊: Jpn J Clin Oncol
• 影响因子: 2.4
• 作者: Ikeda A;Kawai K;Miyazaki J;Nishiyama H.
• 通讯作者: Nishiyama H.

Risk Factors for Intravesical Recurrence in Patients with High-grade T1 Bladder Cancer in the Second TUR Era

• DOI: 10.1093/jjco/hyt016
• 发表时间: 2013-04-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Takaoka, Ei-ichiro;Matsui, Yoshiyuki;Nishiyama, Hiroyuki
• 通讯作者: Nishiyama, Hiroyuki