The Biological Role of SCC Antigen in Head and Neck Cancer

SCC 抗原在头颈癌中的生物学作用

• 批准号: 15591820
• 负责人: NAKASHIMA Torahiko
• 金额: $ 1.98万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591820/
• 关键词: Head and Neck Cancer; SCC Antigen; Sinonasal papilloma; serpin; 癌浸潤

Serine proteases have important roles in tumor invasion and metastasis and their inhibitors, serine protease inhibitors (serpins) are attractive targets for therapeutic strategies. On chromosome 18q21,there is a cluster of serpins ; maspin, headpin, and SCCA1. Others and we have reported that the expression of these serpins are down-regulated in HNSCC cells as compared to normal squamous epithelial cells. We have hypothesized that expression of SCCA1 is biologically disadvantageous to HNSCC cells. The in vitro and in vivo invasion of established HNSCC cell lines stably transfected with a mammalian expression vector with SCCA1 cDNA was significantly inhibited compared to the vector control. SCCA1 may function to inhibit the invasive potential of HNSCC.We also reported that Serum SCC antigen level has a correlation with disease status of sinonasal inverted papilloma(IP) and has a potential to serve as a useful tool for monitoring the course of disease. SCC antigen is a reliable tumor marker in the management ofsinonasal IPs.

丝氨酸蛋白酶在肿瘤的侵袭和转移中起着重要作用，其抑制物、丝氨酸蛋白酶抑制物(Serpins)是治疗策略的重要靶点。在染色体18q21上，有一簇蛇类；maspin、Headpin和SCCA1。我们已经报道，与正常鳞状上皮细胞相比，HNSCC细胞中这些蛇蛋白的表达下调。我们假设SCCA1的表达对HNSCC细胞在生物学上是不利的。与载体对照相比，稳定表达SCCA1基因的哺乳动物表达载体对已建立的HNSCC细胞株的体外和体内侵袭均有明显的抑制作用。SCCA1可能具有抑制HNSCC侵袭潜能的作用。我们还报道，血清SCC抗原水平与鼻窦内翻性乳头状瘤(IP)的病情有关，有可能成为监测病程的有用工具。鳞状细胞癌抗原是治疗鼻窦IP的可靠肿瘤标记物。

项目成果

Yasumatsu R, Kuratomi Y, Nakashima T, et al.: "Cyclin D1 expression does not effect cell proliferation in adenoid cystic carcinoma of the salivary gland"Eru Arch Otorhinolaryngol.. (印刷中). (2004)

Yasumatsu R、Kuratomi Y、Nakashima T 等人：“细胞周期蛋白 D1 表达不会影响唾液腺腺样囊性癌中的细胞增殖”Eru Arch Otorhinolaryngol..（出版中）。

The effect of cyclin D1 overexpression in human head and neck cancer cells.

细胞周期蛋白 D1 过度表达对人头颈癌细胞的影响。

• 发表时间: 2004
• 期刊: Eur.Arch Otorhinolaryngol Epub ahead of print)
• 作者: Nakashima T;Yasumatsu R et al.
• 通讯作者: Yasumatsu R et al.

Effect of the angiotensin-1 converting enzyme inhibitor perindopril on tumor growth and angiogenesis in head and neck squamous cell carcinoma cells.

血管紧张素1转换酶抑制剂培哚普利对头颈鳞状细胞癌细胞肿瘤生长和血管生成的影响。

• 发表时间: 2004
• 期刊: J Cancer Res Clin Oncol 130・10
• 作者: Yasumatsu R;Nakashima T;et al.
• 通讯作者: et al.

鼻副鼻腔内反性乳頭腫における血清SCC抗原測定の意義

鼻窦睑内翻乳头状瘤血清SCC抗原测定的意义

• 发表时间: 2004
• 期刊: 日鼻誌 43・1
• 作者: 安松隆治;中島寅彦他
• 通讯作者: 中島寅彦他

Effect of the angiotensin-I converting enzyme inhibitor perindopril on tumor growth and angiogenesis in head and neck squamous cell carcinoma cells.

血管紧张素-I 转换酶抑制剂培哚普利对头颈鳞状细胞癌细胞肿瘤生长和血管生成的影响。

• 发表时间: 2004
• 期刊: J Cancer Res Clin Oncol 130・10
• 作者: Yasumatsu R;Nakashima T;et al.
• 通讯作者: et al.