Chemoprevention of Head and neck Cancer utilizing an animal model

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Management of second primary cancers in head nad neck cancer(HNC) patients has been important for head and neck surgeons. There are 20-30% incidence of second primary cancer due to field cancerization of the upper aerodigestive tract.This study investigated the efffect of retinoic acids for the chemoprevention of HNC utilizing an animal (hamster) model.13-cis retinoic acid had a effect for preventing cancer in the animal, however no stastisical significance was obtained because the number of animals in the experiment was still small. The experiments are still in progress.