The role of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD)expression in 5-FU based chemoradiation for head and neck cancer

胸苷酸合成酶 (TS) 和二氢嘧啶脱氢酶 (DPD) 表达在基于 5-FU 的头颈癌放化疗中的作用

• 批准号: 20592021
• 负责人: NAKASHIMA Torahiko
• 金额: $ 2.83万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592021/
• 关键词: 頭頸部癌; 放射線化学療法; 核酸代謝酵素; フッ化ピリミジン; TS; DPD

Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) are key enzymes for 5-FU metabolism. The relationship between the expression of TS/DPD and 5-FU sensitivity in head and neck squamous carcinoma (HNSCC) cells was analyzed in vitro.Increasing the expression of TS or DPD decreased the cytotoxicity of 5-FU against HNSCC cells.Clinico-pathological analysis was also performed utilizing specimens from oral cancer and maxillary sinus cancer. There was a correlation between high TS expression and poor prognosis of the patients. Assessment of TS/DPD activity may be useful in predicting the effect and prognosis of HNSCC patients who are receiving 5-FU based chemo(radio)therapy.

胸苷酸合成酶（TS）和二氢嘧啶脱氢酶（DPD）是5-FU代谢的关键酶。本研究采用体外培养的方法，分析TS/DPD表达与头颈鳞癌细胞对5-FU敏感性的关系，发现TS或DPD表达的增加可降低5-FU对头颈鳞癌细胞的杀伤作用，并对口腔癌和上颌窦癌进行临床病理分析。TS高表达与患者预后不良有关。TS/DPD活性的评估可能有助于预测接受5-FU化疗（放疗）的HNSCC患者的疗效和预后。

项目成果

Concurrent chemoradiotherapy with intraarterial CDDP/DOC and S-1 American Academy of Otolaryngology

动脉内 CDDP/DOC 和 S-1 同步放化疗 美国耳鼻喉科学会

• 发表时间: 2009
• 作者: Torahiko Nakashima;Hideki Shiratsuchi;Ryuji Yasumatsu;Shizuo Komune
• 通讯作者: Shizuo Komune

頭頸部扁平上皮癌におけるThymidilate synthase発現とその役割について

胸苷酸合成酶在头颈部鳞状细胞癌中的表达及其作用

• 发表时间: 2008
• 作者: 安松隆治、中島寅彦;他
• 通讯作者: 他

The role of dihydropyrimidine dehydrogenase expression in resistance to 5-Fluorouracil in head and neck squamous cell carcinoma cells.

二氢嘧啶脱氢酶表达在头颈鳞状细胞癌细胞对5-氟尿嘧啶耐药中的作用。

• 发表时间: 2009
• 期刊: Oral Oncol. 45(2)
• 作者: Yasumatsu R;Nakashima T;Uryu H;Masuda M;Hirakawa N;Shiratsuchi H;Tomita K;Fukushima M;Komune S
• 通讯作者: Komune S

Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma.

胸苷酸合酶表达作为上颌窦鳞状细胞癌患者对基于 5-氟尿嘧啶的放化疗临床反应的预测因子。

• 发表时间: 2010
• 期刊: Auris Nasus Larynx in press
• 作者: 安松隆治,中島寅彦;et al.
• 通讯作者: et al.

Relative level of thymidylate synthase mRNA expression in primary tumors and normal tissues predicts survival of patients with oral tongue squamous cell carcinoma

原发性肿瘤和正常组织中胸苷酸合酶 mRNA 表达的相对水平可预测口腔舌鳞状细胞癌患者的生存

• 发表时间: 2010
• 期刊: Eur Arch Otorhinolaryngol 267
• 作者: Yasumatsu R;Nakashima T;et al.
• 通讯作者: et al.