The Molecular Mechanism of SCC Antigen Expression in Head and Neck Cancer

SCC抗原（SCCA）在正常上皮中表达，并且SCC抗原的血清水平不仅在癌症患者中升高，而且在良性炎性疾病如支气管哮喘和肺炎中也升高。然而，SCCA过度表达的分子机制仍不清楚。我们以前曾报道过，头颈部鳞状细胞癌（HNSCC）组织周围的T淋巴细胞过度表达SCCA，并负责SCC抗原的血清升高。TNF-α刺激T淋巴细胞诱导SCC抗原表达，表明肿瘤细胞表达的细胞因子诱导SCCA表达。我们还将SCCA（SCCA 1）转染到培养的HNSCC细胞中，在Matrigel实验中发现SCCA 1的表达显著抑制HNSCC细胞的体外侵袭。此外，SCCA 1的表达也抑制了裸鼠体内的生长和侵袭。

The SCC antigen (SCCA) is expressed in normal epithelium and the serum level of SCC antigen is elevated not only in cancer patients but also in benign inflammatory diseases such as bronchial asthma and pneumonia. However, the molecular mechanism of the overexpression of SCCA is still unclear. We have previously reported that T lymphocytes surrounding head and neck sqouamous cell carcinoma (HNSCC) tissue are overexpressing SCCA and are responsible for the serum elevation of SCC antigen. TNF-alfa stimulation of T-lymphocytes induced SCC antigen expression suggesting that cytokines expressed by the tumor cells induce SCCA expression. Continuous research is on going regarding the mechanism of SCCA expression.We have also transfected SCCA (SCCA1) to cultured HNSCC cells and showed that SCCA1 expression significantly inhibited the in vitro invasion in matrigel assays. Furthermore, the in vivo growth and invasion in nude mice was also inhibited by SCCA1 expression.