The Molecular Mechanism of SCC Antigen Expression in Head and Neck Cancer

头颈癌SCC抗原表达的分子机制

• 批准号: 17591793
• 负责人: NAKASHIMA Torahiko
• 金额: $ 2.11万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591793/
• 关键词: SCC Antigen; Head and Neck Cancer

The SCC antigen (SCCA) is expressed in normal epithelium and the serum level of SCC antigen is elevated not only in cancer patients but also in benign inflammatory diseases such as bronchial asthma and pneumonia. However, the molecular mechanism of the overexpression of SCCA is still unclear. We have previously reported that T lymphocytes surrounding head and neck sqouamous cell carcinoma (HNSCC) tissue are overexpressing SCCA and are responsible for the serum elevation of SCC antigen. TNF-alfa stimulation of T-lymphocytes induced SCC antigen expression suggesting that cytokines expressed by the tumor cells induce SCCA expression. Continuous research is on going regarding the mechanism of SCCA expression.We have also transfected SCCA (SCCA1) to cultured HNSCC cells and showed that SCCA1 expression significantly inhibited the in vitro invasion in matrigel assays. Furthermore, the in vivo growth and invasion in nude mice was also inhibited by SCCA1 expression.

SCC抗原（SCCA）在正常上皮中表达，并且SCC抗原的血清水平不仅在癌症患者中升高，而且在良性炎性疾病如支气管哮喘和肺炎中也升高。然而，SCCA过度表达的分子机制仍不清楚。我们以前曾报道过，头颈部鳞状细胞癌（HNSCC）组织周围的T淋巴细胞过度表达SCCA，并负责SCC抗原的血清升高。TNF-α刺激T淋巴细胞诱导SCC抗原表达，表明肿瘤细胞表达的细胞因子诱导SCCA表达。我们还将SCCA（SCCA 1）转染到培养的HNSCC细胞中，在Matrigel实验中发现SCCA 1的表达显著抑制HNSCC细胞的体外侵袭。此外，SCCA 1的表达也抑制了裸鼠体内的生长和侵袭。

项目成果

Effects of a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on growth, apoptosis, gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell lines

新型 NF-κB 抑制剂去羟甲基环氧喹诺星 (DHMEQ) 对头颈鳞状细胞癌细胞系生长、凋亡、基因表达和化疗敏感性的影响

• 发表时间: 2006
• 期刊: Head and Neck 28・2
• 作者: Ruan HY;Masuda M;Ito A;Umezawa K;Nakashima T et al.
• 通讯作者: Nakashima T et al.

Multidimensional voice evaluation in pretreatment glottic carcinoma

• DOI: 10.1159/000084137
• 发表时间: 2005-01-01
• 期刊: FOLIA PHONIATRICA ET LOGOPAEDICA
• 影响因子: 1
• 作者: Matsubara, N;Umezaki, T;Komiyama, S
• 通讯作者: Komiyama, S

Expression of laminin 5 basement membrane components in invading and recurring adenoid cystic carcinoma of the head and neck.

层粘连蛋白5基底膜成分在头颈部侵袭性和复发性腺样囊性癌中的表达。

• 发表时间: 2006
• 期刊: Auris Nasus Larynx 33
• 作者: Kumamoto M;Kuratomi Y;Yasumatsu R;Nakashima T et al.
• 通讯作者: Nakashima T et al.

GABA-induced response in spiral ganglion cells acutely isolated from guinea pig cochlea

• DOI: 10.1016/j.neures.2005.08.011
• 发表时间: 2005-12
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: T. Nakagawa;M. Yamashita;K. Hisashi;S. Usami;Y. Kakazu;S. Shibata;T. Nakashima;K. Koike;K. Kubo;S. Komune

Role of squamous cell carcinoma antigen 1 expression in the invasive potential of head and neck squamous cell carcinoma

• DOI: 10.1002/hed.20293
• 发表时间: 2006-01-01
• 期刊: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
• 影响因子: 2.9
• 作者: Nakashima, T;Yasumatsu, R;Komune, S
• 通讯作者: Komune, S